天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (1): 31-34.doi: 10.16333/j.1001-6880.2015.01.006

• 研究论文 • 上一篇    下一篇

乳香精油抗抑郁作用的研究

张业奇1,邓鲲华1,杨怡1,王玉婷1,王诗2*,丁虹1*   

  1. 1 武汉大学药学院,武汉 430072;2 湖北科技学院药学院,咸宁437100
  • 出版日期:2015-01-31 发布日期:2015-02-12

Anti-depression Effect of Frankincense Essential Oil

ZHANG Ye-qi1, DENG Kun-hua1, YANG Yi1, WANG Yu-ting1, WANG Shi2*, DING Hong1*   

  1. 1 School of Pharmaceutical Sciences,Wuhan University,Hubei Wuhan 430072,China; 2 School of Pharmacy,Hubei University of Science and Technology, Hubei Xianning 437100,China
  • Online:2015-01-31 Published:2015-02-12

摘要: 为探讨乳香精油的抗抑郁作用及其可能机制,以慢性轻度不可预见性应激方法建立小鼠抑郁症模型,造模同时每日灌胃给药。用旷场实验、悬尾实验、强迫游泳实验对小鼠进行行为学评测,并用高效液相——电化学方法检测小鼠大脑内5-HT含量。试验显示,0.1、0.2 mL/100 g的乳香精油可不同程度地改善小鼠的行为学行为,显著提高小鼠脑内的5-HT含量(P<0.05)。乳香精油具有抗抑郁作用,对中枢单胺类神经递质5-HT的调节是其作用机制之一。

关键词: 乳香精油, 慢性不可预见性应激, 抗抑郁, 行为学, 5-羟色胺

Abstract: The aim of this research was to explore the anti-depression effect of frankincense essential oil and its possible mechanism.Chronic unpredictable mild stress (CUMS) model was established and the model mice were intraperitioneally injected with the essential oil on the same day.The open-field test,forced swimming test (FST) and tail suspending test (TST) were then carried to observe and evaluate the ethological changes in model mice.By using HPLCECD,content of 5-HT in brain was determined.The results revealed that frankincense essential oil with the concentration of 0.1,0.2 mL/100 g can influence behaviors of mice differently,including the increase of the frequency of crossing in the open-field test and the decrease of the motionless time in the FST.Besides,both concentration of frankincense essential oil increased the content of 5-HT in brain significantly (P<0.05).The results suggested that frankincense essential oil has anti-depression effect which may be related to the regulation of 5-HT in brain.

Key words: Frankincense essential oil, the chronic unpredictable mild stress, depression behavior, anti-depression effect, 5-HT

中图分类号: 

R964 R285.5