天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (Suppl): 100-103.doi: 10.16333/j.1001-6880.2015.S.025

• 开发研究 • 上一篇    下一篇

叶黄素二丁二酸钠的合成及其理化性质分析

崔巍1,李芬芳1*,谭志坚2   

  1. 1 中南大学化学化工学院,长沙 410083;2 中国农业科学院麻类研究所,长沙 410205
  • 出版日期:2015-12-01 发布日期:2016-01-12

Synthesis of Lutein Disuccinate Sodium Salt and Analysis of Its Properties

CUI Wei1,LI Fen-fang1*,TAN Zhi-jian2   

  1. 1 School of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China; 2 Institute of Bast Fiber Crops,Chinese Academy of Agricultural Sciences,Changsha 410205,China
  • Online:2015-12-01 Published:2016-01-12

摘要: 叶黄素分子中含有多个共轭双键,导致其水溶性和稳定性较差,极大地限制了其生物利用度。实验采用三乙胺催化叶黄素和丁二酸酐合成叶黄素二丁二酸酯,并采用单因素法对反应条件进行优化。最佳反应条件为以三乙胺作催化剂,温度35 ℃,反应时间12 h,叶黄素与丁二酸酐摩尔比1:5。最后采用甲醇钠合成叶黄素二丁二酸钠(Lds),其在水中溶解度约为23.32 mg/mL,而叶黄素几乎不溶于水。同时考察了温度、光照等因素对其保存率的影响。实验结果表明叶黄素二丁二酸钠稳定性和抗氧化性均优于叶黄素,且在保存过程中应避免高温、光照、酸性条件及氧气的存在。

关键词: 叶黄素, 叶黄素酯, 水溶性, 稳定性, 抗氧化性

Abstract: Lutein has many conjugated double bonds,which lead to poor aqueous solubility and stability and constrain its application in commercial and clinical fields heavily.Somewhat differently triethylamine was used as the catalyst to synthesis the lutein disuccinate by lutein and succinic anhydride and the effect of the temperature,reaction time and molar ratio on the yield was determined by the single factor experiment.The results indicated that the optimum condition as follow,reaction time was 12 h,temperature was 35 ℃,molar ratio(lutein:succinic anhydride) was 1:5.Finally,lutein disuccinate sodium salt(Lds) was synthesized by CH3ONa.The aqueous solubility of Lds was 22.32 mg/ml,but lutein could be barely solved in water and its stability to light,heat and pH was tested.In addition,the hydroxyl free radical scavenging ability was also investigated.The results suggested that Lds had better stability and antioxidant activity than lutein.In order to better preserve Lds,heat,light,acid and air should be avoid.

Key words: lutein, lutein esters, watersolubility, stability, antioxidant activity

中图分类号: 

O624.32