天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (8): 1319-1324.doi: 10.16333/j.1001-6880.2016.8.027

• 开发研究 • 上一篇    下一篇

复方独一味凝胶贴膏的处方优化和制备工艺研究

王森1,欧水平2*,袁涛3   

  1. 1 遵义医学院;2遵义医学院附属医院,遵义 563003;3江西青峰药业有限公司,赣州 341008
  • 出版日期:2016-08-30 发布日期:2017-01-17

Optimization and Preparation of Prescriptions of Compound Duyiwei Gel Plasters

WANG Sen1,OU Shui-ping2*,YUAN Tao3   

  1. 1 School of Pharmacy,Zunyi Medical University;2First Affiliated Hospital of Zunyi Medical University, Zunyi 563003,China;3Jiangxi Qinfeng Pharmaceutical Co.Ltd,Jiangxi,Ganzhou 341008,China
  • Online:2016-08-30 Published:2017-01-17

摘要: 以初黏力、赋形性、综合感官为评价指标,采用Box-Behnken设计对基质处方进行优化,以流变性为评价指标筛选载药量,采用延压法涂布制备,考察物料添加顺序、搅拌速度与时间、干燥温度和时间等工艺参数。优选的基质处方为ViscomateTMNP700 5.0 g、甘羟铝 0.14 g、甘油 25 g、EDTA 0.2 g,载药量84 g浸膏。制备的复方独一味凝胶贴膏的外观光滑平整,具有适宜的黏附性,无膜残留,皮肤追随性较好,制备工艺简单、稳定、可行。

关键词: 复方独一味凝胶贴膏, Box-Behnken设计, 基质处方, 流变性

Abstract: Taking the initial adhesion,forming property and comprehensive sense as evaluation indexes to optimize the matrix formulation of Compound Duyiwei Gel Plasters.Using the rheological property as evaluation indexes to screen the drug loading.Calendering processing was used to prepare Compound Duyiwei Gel Plasters,and the process parameters,including the material adding order,stirring speed and time,drying temperature and time,were investigated.The preferred matrix formulation was as follows:ViscomateTM NP700 5.0 g,Aluminium glycinate 0.14 g,glycerol 25 g,EDTA 0.2 g,and the drug loading was 84 g fluid extract.The compound Duyiwei gel plasters prepared by the optimized prescription and preparation technique was smooth,with appropriate adhesion and without residual behavior,and was feasible for following the skin.

Key words: Compound duyiwei gel plasters, Box-Behnken design, matrix formulation, rheological property

中图分类号: 

R283.6