天然产物研究与开发 ›› 2018, Vol. 30 ›› Issue (11): 2023-2031.doi: 10.16333/j.1001-6880.2018.11.027

• 综述 • 上一篇    

罗汉果甜苷降糖机制及生物合成研究进展

刘灿1,2,马兰青1*,孙媛霞2*   

  1. 1北京农学院生物科学与工程学院 农业部华北都市农业重点实验室,北京 102206;2中国科学院 天津工业生物技术研究所,天津 300308
  • 出版日期:2018-12-03 发布日期:2018-12-03
  • 基金资助:

    北京自然科学基金(7174283);北京林果业生态环境功能提升协同创新中心项目(CEFF-PMX20170142070 00043)

Hypoglycemic Mechanisms and Biosynthesis of Mogrosides from Siraitia grosvenorii Fruit:A Review

LIU Can1,2, MA Lan-qing1*, SUN Yuan-xia2*   

  1. 1Key Laboratory of Urban Agriculture (North China),Ministry of Agriculture,College of Biological Science and Engineering,Beijing University of Agriculture,Beijing 102206,China; 2Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China
  • Online:2018-12-03 Published:2018-12-03

摘要: 甜苷是罗汉果中具有降糖作用的葫芦烷三萜类化合物,其血糖调节机制复杂,迄今尚未完全阐明。此外,甜苷含量低,通过对甜苷合成代谢中关键酶的克隆与功能表征有效增加其产量。本文综述了罗汉果甜苷的降糖机制及分子合成途径,探讨了当前研究所面临的问题,以期为甜苷的药物开发和生物合成研究提供参考。

关键词: 罗汉果甜苷, 血糖调控, 三萜化合物, 生物合成

Abstract: Mogrosides are components of cucurbitane triterpenes,have hypoglycemic activity,and are found in the fruit Siraitia grosvenorii.The mechanism by which mogrosides reduced blood sugar was complex and needed to be interpreted;in addition,there was a problem of low content of mogrosides in Siraitia grosvenii,and biosynthesis was an attractive way to produce mogrosides on a large scale.In terms of biosynthesis of mogrosides,the key enzymes have been cloned and expressed,which provided the basis for mogroside synthesis and the establishment of cell factories.In this paper,the hypoglycemic effect and the progress of the biosynthesis mechanism of mogrosides was reviewed,which provided the reference for advancing the development and biosynthesis of mogrosides.

Key words: Mogrosides, glycemia regulation, triterpene, biosynthesis

中图分类号: 

R282.71