天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (10): 1783-1790.doi: 10.16333/j.1001-6880.2019.10.017

所属专题: No.6

• 开发研究 • 上一篇    下一篇

新疆榅桲抗动脉粥样硬化“多成分-多靶点”作用机制的网络药理学研究

吉米丽汗·司马依1,艾尼瓦尔·吾买尔1,买尔旦·玉苏甫1,阿地力江·萨吾提1,买买提明·努尔买买提2,周文婷1*   

  1. 1新疆医科大学药学院;2新疆医科大学维吾尔医学院,乌鲁木齐 830011
  • 出版日期:2019-10-28 发布日期:2019-11-11
  • 基金资助:

    国家自然科学基金(81660696);新疆维吾尔自治区中医民族医药管理局-新疆地产中药民族药新药研发培育项目(2017-02-05);新疆医科大学博士后科研启动基金项目(170401);新疆自治区“十三五”重点学科建设项目(2016)

Study on the mechanism of anti-atherosclerosis effect of Cydonia Oblanga Mill. in Xinjiang based on network pharmacology

SIMAYI Jimilihan1,WUMAIER Ainiwaer1,YUSUFU Maierdan1,SAWUTI Adilijiang1,NUERMAIMAITI Maimaitiming2,ZHOU Wen-ting1*   

  1. 1Department of Pharmacology;2Department of Uyghur Medical,Xinjiang Medical University,Urumqi 830011,China
  • Online:2019-10-28 Published:2019-11-11

摘要: 本文通过网络药理学方法研究新疆榅桲活性成分其作用靶点,并构建成分-靶点-通路网络探讨其抗动脉粥样硬化多成分-多靶点-多通路的作用机制。本文从不同数据库收集得到10个与动脉粥样硬化相关的主要活性成分,预测得到10个主要作用靶点,调控了血管平滑肌细胞增殖、白脂肪细胞分化等生物学功能,参与了PPAR等信号通路,体现了新疆榅桲多成分、多靶点、多通路的作用特点,为阐述其抗动脉粥样硬化的作用机制提供科学依据。

关键词: 网络药理学, 榅桲, 动脉粥样硬化, 活性成分, 作用靶点

Abstract: To study the active compounds and their targets of Xinjiang Cydonia Oblanga Mill.(COM) by network pharmacological method,and to construct a component-target-pathway network to explore its anti-atherosclerosis “multi-components,multi-targets,multi-pathways” mechanism.Ten main active compounds related to atherosclerosis were collected from different databases,and 10 main targets were predicted,which involved in the biological functions of vascular smooth muscle cell proliferation,white adipocyte differentiation,and participated in PPAR signaling pathways,reflecting the multi-components,multi-targets and multi-pathways mechanism of COM.The characteristics provide a scientific basis for explaining the mechanism of atherosclerosis.

Key words: network pharmacology, Cydonia Oblanga Mill., atherosclerosis, active compound, target of action

中图分类号: 

R966