负载5-氟尿嘧啶的黄芪多糖/聚乳酸微球的制备及其促免疫细胞增殖活性的研究

doi:10.16333/j.1001-6880.2019.S.023

天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (增刊1): 131-135.doi: 10.16333/j.1001-6880.2019.S.023

负载5-氟尿嘧啶的黄芪多糖/聚乳酸微球的制备及其促免疫细胞增殖活性的研究

夏韵雅，鲍慧，徐达达，张伟杰*

兰州理工大学生命科学与工程学院，兰州730050

出版日期:2019-08-06 发布日期:2019-08-06
基金资助:
国家自然科学基金（81560737）

Study on the release and immunostimulatory activity of 5-FU-loaded Astragalus polysaccharide/PLA microspheres

XIA Yun-ya,BAO Hui,XU Da-da,ZHANG Wei-jie*

School of Life science and engineering,Lanzhou University of Technology,Lanzhou 730050,China

Online:2019-08-06 Published:2019-08-06

摘要/Abstract

摘要： 为开发利用黄芪多糖提高微球的载药能力的可行性。实验通过溶剂蒸发法制备负载APS / 5-FU的聚乳酸（PLA）微球。通过扫描电子显微镜（SEM）和FT-IR测定复合微球的结构，以及制备的两组微球（添加APS / 5-FU / PLA，无APS / 5-FU / PLA）的载药性能。结果表明，加入APS后，PLA微球具有较高的载药量，包封率和免疫刺激活性。负载APS 的 5-FU/PLA微球作为缓释的药物载体显示出巨大的潜力。

关键词: APS, 微球, 促免疫细胞增殖, 释放曲线

Abstract: The purpose of this study was to develop the feasibility of using Astragalus polysaccharides to increase the drug-loading capacity of microspheres.APS/5-FU loaded polylactic acid (PLA) microspheres were prepared by solvent evaporation.The structure of the composite microspheres was determined by scanning electron microscopy (SEM) and FT-IR,and the drug-loading properties of the prepared microspheres (adding APS / 5-FU / PLA,no APS / 5-FU / PLA) were investigated.The results showed that PLA microspheres had higher drug loading,encapsulation efficiency and immunostimulatory activity after the addition of APS.The AFU-loaded 5-FU/PLA microspheres show great potential as a drug carrier for sustained release.

Key words: APS, microspheres, immunostimulatory activity, drug release

中图分类号:

R318.08

夏韵雅，鲍慧，徐达达，张伟杰*. 负载5-氟尿嘧啶的黄芪多糖/聚乳酸微球的制备及其促免疫细胞增殖活性的研究[J]. 天然产物研究与开发, 2019, 31(增刊1): 131-135.

XIA Yun-ya,BAO Hui,XU Da-da,ZHANG Wei-jie*. Study on the release and immunostimulatory activity of 5-FU-loaded Astragalus polysaccharide/PLA microspheres[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(增刊1): 131-135.

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负载5-氟尿嘧啶的黄芪多糖/聚乳酸微球的制备及其促免疫细胞增殖活性的研究

Study on the release and immunostimulatory activity of 5-FU-loaded Astragalus polysaccharide/PLA microspheres

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