天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (2): 278-287.doi: 10.16333/j.1001-6880.2020.2.012

• 开发研究 • 上一篇    下一篇

复方精油香气抗抑郁作用研究

王莹1#,陶凤瑛2#,崔东红2,刘玉敏3,吴亚妮1*   

  1. 1上海交通大学设计学院;2上海交通大学医学院附属精神卫生中心;3上海交通大学分析测试中心,上海 200240
  • 出版日期:2020-02-29 发布日期:2020-04-23
  • 基金资助:

    上海市重性精神病重点实验室项目(14-k09)

Study on the anti-depressant effect of compound essential oil

WANG Ying1#,TAO Feng-ying2#,CUI Dong-hong2,LIU Yu-min3,WU Ya-ni1*   

  1. 1School of Design,Shanghai Jiaotong University;2Mental Health Center Affiliated to Medical College,Shanghai Jiaotong University;3Analysis and Testing Center of Shanghai Jiaotong University,Shanghai 200240,China
  • Online:2020-02-29 Published:2020-04-23

摘要: 研究复方精油香气经由人体嗅吸通路对抑郁症康复的辅助干预作用,运用GC-MS(气相色谱质谱联用技术)对抗抑郁复方精油的主要成分进行分析,同时通过尿液代谢组学研究方法,对样本中的代谢物检测分析,鉴定差异代谢物,寻找相关代谢通路。研究表明,抗抑郁复方精油共鉴定出41种化合物,主要为萜烯、醇、酯类等;精油香气干预前后,在抑郁症患者的尿液样本中发现甘氨酸,牛磺酸,丝氨酸等6个代谢物发生了显著变化,涉及到牛磺酸代谢及甘氨酸、丝氨酸、苏氨酸代谢通路。表明抑郁症患者在康复阶段可以通过嗅吸精油香气经由对神经递质、牛磺酸等代谢途径的调节,发挥纾解抑郁症状的作用。

关键词: 代谢组学, 精油, 香气, 抑郁

Abstract: To study the mechanism of aroma in relieving depressive symptoms,the main components of anti-depressant compound essential oil were analyzed by gas chromatography-mass spectrometry (GC-MS).Meanwhile,the metabolites of urine samples were detected and analyzed by the method of urine metabonomics to identify the differential metabolites and find the related metabolic pathway.The results showed that 41 compounds,including terpenes,alcohols,esters,have been identified in the anti-depressant compound essential oil.In human urine samples,six metabolites,including glycine,taurine and serine,were found to change significantly before and after aromas treatment,involving taurine metabolism and glycine,serine and threonine metabolic pathways.This suggests that aromatherapy can alleviate depression by regulating neurotransmitters,taurine and other metabolic pathways in patients with depression.

Key words: metabonomics, essential oil, aroma, depression

中图分类号: 

R277.7