天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (4): 659-664.doi: 10.16333/j.1001-6880.2020.4.016

• 开发研究 • 上一篇    下一篇

降尿酸复方抗痛风的药效学和急性毒性研究

王芳,曹静,李阳,白静,徐海波,国锦琳*   

  1. 成都中医药大学 西南特色中药资源省部共建国家重点实验室 中药材标准化教育部重点实验室,成都 611137

  • 出版日期:2020-04-28 发布日期:2020-06-05
  • 基金资助:
    四川省青年科技创新团队(2019CXTD0055)

Study on pharmacodynamics and acute toxicity of antigout with antiuric acid compound

WANG Fang, CAO Jing, LI Yang, BAI Jing, XU Hai-bo, GUO Jin-lin*   

  1. Key Laboratory of Standardization of Chinese Medicine, Ministry of Education;Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

  • Online:2020-04-28 Published:2020-06-05

摘要: 降尿酸复方抗高尿酸血症的疗效研究并评价其在临床用药上的安全性。对实验动物使用氧嗪酸钾灌胃造模,用热板和化学刺激法来衡量药物的镇痛作用,用小鼠耳肿胀探讨抗炎效果,并解剖染色观察药物是否对主要脏器产生影响,临床用药安全性则采用更符合此研究实际情况的最大给药量实验来进行评价。结果表明此复方可明显降低模型大鼠血清中的尿素氮和尿酸的含量,不破坏主要脏器,且一定程度上减轻了高尿酸血症引发的肝、肾组织病变,还可以减少化学刺激痛模型小鼠的扭体次数,增加热板刺激痛实验中模型小鼠的痛阈值,明显地降低耳肿胀模型小鼠的耳肿胀度。因此降尿酸复方可以明显降低体内尿酸含量,具有抗炎镇痛作用,急性毒性实验表明复方安全无毒。


关键词:

Abstract:

In this paper, the efficacy and clinical safety of antiuric acid formula in the treatment of hyperuricemia and gout were studied. Uric acid enzyme inhibitor (potassium oxazine acid) was used to model, and analgesic, anti-inflammatory and safety experiments were carried out. The result shows that antiuric acid formula could significantly reduce the levels of uric acid and urea nitrogen in serum of model rats. To some extent, it can reduce the pathological changes of liver and kidney caused by hyperuricemia, reduce the number of writhing in mice induced by chemical stimulation of pain, increase the pain threshold of mice stimulated by hot plate, and obviously reduce the swelling degree of ears induced by xylene in mice. The maximum dosage test determined its edible safety. Therefore, antiuric acid formula can obviously reduce the content of uric acid in the body, has anti-inflammatory and analgesic effect, acute toxicity indicates that it is nontoxic.

Key words: uric acid-lowering compound, pharmacodynamics, acute toxicity, hyperuricemia, anti-inflammatory and analgesic

中图分类号:  R965.1