天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (8): 1316-1323.doi: 10.16333/j.1001-6880.2020.8.006

所属专题: No.1

• 研究论文 • 上一篇    下一篇

基于网络药理学的血必净注射液干预细胞因子风暴辅助治疗重症新型冠状病毒肺炎的潜在机制研究

吉米丽汗·司马依1,买买提明·努尔买买提2,艾尼瓦尔·吾买尔1,买尔旦·玉苏甫1,卡依赛尔·阿布都肉苏力,木哈待斯·努尔1,努丽比亚·买合木提1,周文婷1*   

  1. 1新疆医科大学药学院;2新疆医科大学维吾尔医学院,乌鲁木齐 830011

  • 出版日期:2020-08-28 发布日期:2020-09-02
  • 基金资助:
    国家自然科学基金(81660696);新疆维吾尔自治区中医民族医药管理局-新疆地产中药民族药新药研发培育项目(2017-02-05);新疆医科大学博士后科研启动基金(170401);新疆自治区“十三五”重点学科建设项目(2016)

Study on the mechanism of Xuebijing injection based on network pharmacology for intervention of cytokine storm adjuvant therapy in severe COVID-19

JIMILIHAN Si-ma-yi1,MAIMAITIMING Nu-er-mai-mai-ti2,AINIWAER Wu-mai-er1,MAIERDAN Yu-su-fu1, KAYISAIER A-bu-du-rou-su-li1,MUHADAISI Nu-er1,NULIBIYA Mai-he-mu-ti1,ZHOU Wen-ting 1*#br#

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  1. 1Department of Pharmacology;2Department of Uyghur Medical,Xinjiang Medical University,Urumqi 830011,China

  • Online:2020-08-28 Published:2020-09-02

摘要: 2019年12月底于我国湖北省武汉市爆发新型冠状病毒肺炎(COVID-19),截止2020年4月30日,我国共确诊病例8万余,全球已确诊病例300余万,其传染性强,传播迅速广泛,引起了国内外高度关注。重症患者可因“细胞因子风暴”在中低热甚至无明显发热病程中快速进展为急性呼吸窘迫综合征、多器官衰竭等严重并发症。目前在《新型冠状病毒感染的肺炎诊疗方案》中要求加强中西医结合,中西医结合治疗也收到了积极效果。本文运用网络药理学方法探讨血必净注射液辅助治疗重症COVID-19与干预细胞因子风暴密切相关的作用路径和潜在的机制靶点,有望对现有的诊疗方案中药临床应用做有益补充,发挥抗击疫情的重要作用。


关键词: 血必净注射液, 新型冠状病毒肺炎, 细胞因子风暴, 网络药理学, 作用机制

Abstract:

Corona virus disease 2019 (COVID-19) broke out in Wuhan,Hubei province in late December 2019.As of April 30,2020,there are more than 80 000 confirmed cases in China and more than 3 million confirmed cases in the world.As of April 30,2020,there are more than 80 000 confirmed cases in China and more than 3 million confirmed cases in the world.They are highly infectious and spread widely.Severe patients can rapidly progress to acute respiratory distress syndrome,multiple organ failure and other serious complications due to "cytokine storm" in the course of moderate and low fever or even no obvious fever.At present,the COVID-19 diagnosis and treatment plan calls for strengthening the integration of Chinese and Western medicine,and the integrative medicine has also achieved positive results.In this paper,the network pharmacology method is used to explore the action path and potential mechanism of Xuebijing injection in the treatment of severe COVID-19,which is closely related to the intervention of cytokine storm.It is expected to make a beneficial supplement to the clinical application of traditional Chinese medicine in the existing diagnosis and treatment scheme,and play an important role in fighting the epidemic.

Key words: Xuebijing injection, COVID-19, cytokine storm, network pharmacology, mechanism of action

中图分类号:  R966