天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (9): 1606-1613.doi: 10.16333/j.1001-6880.2020.9.020

• 综述 • 上一篇    下一篇

天然产物活性成分抗肝癌分子机制的研究进展

王为兰,刘晓颖,刘福君,李金耀*   

  1. 新疆大学生命科学与技术学院 新疆生物资源基因工程重点实验室,乌鲁木齐 830046

  • 出版日期:2020-09-28 发布日期:2020-09-25
  • 基金资助:
    新疆大学自然科学博士启动基金(BS150240)

Review on molecular mechanism of active components from natural products against hepatocellular carcinoma

WANG Wei-lan,LIU Xiao-ying,LIU Fu-jun,LI Jin-yao*   

  1. College of Life Science and Technology,Xinjiang Key Laboratory of Biological Resources and Genetic Engineering,Xinjiang University,Urumqi 830046,China

  • Online:2020-09-28 Published:2020-09-25

摘要: 肝癌作为高发病率和高死亡率的恶性肿瘤之一,存在术后复发率高、癌细胞易转移、多药耐药、机体免疫力低下、治疗预后不佳等问题;当前缺乏行之有效的治疗手段,因此迫切寻找安全、高效低毒的新型抗肝癌药物。天然产物富含多类活性成分,如多糖、黄酮、皂苷、生物碱等,具有优先杀伤或抑制癌细胞、毒副作用小、不易产生耐药性、增强机体免疫的作用,且为多靶点、环节效应的特征,是探索新型抗肿瘤药物的重要资源库。目前,从天然产物中提取活性成分,并探究其抗肝癌作用机制是筛选肝癌治疗药物及作用靶点的重要途径和研究热点。本文将从天然产物活性成分抑制肝癌细胞增殖的作用机制进行综述,揭示诱导肝癌细胞凋亡的作用途径,以期为抗肝癌药物的研发与利用提供理论依据。


关键词: 天然产物, 活性成分, 肝癌, 分子机制, 研究进展

Abstract:

Hepatocellular carcinoma is one of the malignant tumors with high morbidity and mortality,which has some problems,such as high postoperative recurrence rate,easy metastasis,multidrug resistance,low immunity,poor prognosis and so on.Currently,there is a lack of effective treatment,so it is extremely urgent to look for new drugs for anti-hepatocellular carcinoma with safety,high efficiency and low toxicity.Natural products are rich in many kinds of active components,such as polysaccharides, flavonoids,saponins, alkaloids,etc., which have the advantages of giving priority to killing or inhibiting cancer cells,less toxic and side effects,not easy to produce drug resistance,enhance immunity,and have the characteristics of multi-target and link effect.It is an important resource bank for exploring new anti-tumor drugs.At present,extracting active components from natural products and exploring their anti-liver cancer mechanism is an important way and research focus to screen therapeutic drugs and targets for hepatocellular carcinoma.The article will review the mechanism of the inhibitory effect of activecomponents of natural products on the proliferation of liver cancer cells,and reveal the pathway of inducing apoptosis of liver cancer cells,in order to provide a theoretical basis for the research and development and utilization of anti-liver cancer drugs.

Key words: medicinal plants, active components, hepatocellular carcinoma, molecular mechanism, reviews

中图分类号:  R96