In order to explore the mechanism of total glucosides of paeony(TGP) in the treatment of sjogrens syndrome,24 female non obese diabetes(NOD) mice aged 8 weeks were randomly divided into model group,hydroxychloroquine(HCQ) group,TGP group and combination group,with 6 mice in each group.TGP group was given 0.4 mL TGP diluted solution daily,HCQ group was given 0.4 mL HCQ diluent every day,and the combination group was given HCQ dilution daily gastric TGP+ HCQ 0.4 mL,model group and normal group were intragastrically given 0.4 mL normal saline.After 8 weeks,the submandibular gland tissues were removed to observe the pathological changes of submandibular gland in each group.The expression of ROR γt mRNA and group.The expression of RORγt mRNA and Foxp3 mRNA in submandibular gland tissue was detected by RT-PCR.The results showed：that the pathological damage of submandibular gland in the model group was significantly more serious than that in the normal group,and other groups were improved to varying degrees after drug intervention,and the combined group was significantly better than HCQ group and TGP group.The expression of RORγt mRNA in submandibular gland of NOD mice in the model group was significantly higher than that in the normal group,while The expression of Foxp3 mRNA was significantly lower than that of the normal group.The expression of RORγt mRNA in the submandibular gland of each treatment group was higher than that of the model group,and the expression of combined group was significantly lower than that of HCQ group and TGP group.The expression of Foxp3 mRNA in submandibular gland of combined group was lower than that of model group,HCQ group and TGP group,and there was significant difference compared with model group.It is suggested that TGP can improve the pathological damage of submandibular gland in NOD mice with sjogren's syndrome,which may play a role in the treatment of SS through the immune balance between Thl7/Treg mediated by RORγt / Foxp3.