天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (9): 1491-1498.doi: 10.16333/j.1001-6880.2021.9.006

• 研究简报 • 上一篇    下一篇

霍山石斛化学成分研究

赵宏苏1,2,许凤清1,2,陈箫箫1,胡江苗3,曾凡俊4,彭代银1,吴德玲1,2*   

  1. 1安徽中医药大学 中药研究与开发安徽省重点实验室;2中药饮片制造新技术安徽省重点实验室,合肥 230012;3中国科学院昆明植物研究所,昆明 650201;4海关总署(北京)国际旅行卫生保健中心,北京 100013

  • 出版日期:2021-09-28 发布日期:2021-09-28
  • 基金资助:
    国家自然科学基金(U19A2009);安徽中医药大学自然科学基金重点项目(2020zrzd14)

Chemical constituents of Dendrobium huoshanense C.Z.Tang et S.J.Cheng

ZHAO Hong-su1,2,XU Feng-qing1,2,CHEN Xiao-xiao1,HU Jiang-miao3,ZENG Fan-jun4,PENG Dai-yin1,WU De-ling1,2*#br#

#br#
  

  1. 1Anhui Province Key Laboratory of Research & Development of Chinese Medicine,Anhui University of Chinese Medicine; 2Anhui Provincial Key Laboratory of New Manufacturing Technology for Traditional Chinese Medicine Decoction Pieces,Hefei 230012,China;3Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;4General Administration of Customs (Beijing) International Travel Health Care Center,Beijing 100013,China


  • Online:2021-09-28 Published:2021-09-28

摘要:

研究霍山石斛Dendrobium huoshanense Tang et Cheng茎的化学成分。应用硅胶、Sephadex LH-20、MCI-gel、Rp-18结合Semi-prep HPLC技术进行分离纯化,从霍山石斛茎中分离得到29个化合物,分别鉴定为4,4′-二羟基-3,5-二甲氧基联苄(1)、batatasin III(2)、5,4′-二羟基-3-甲氧基联苄(3)、二氢松柏醇二氢对羟基桂皮酸酯(4)、对羟基苯丙酸甲酯(5)、二氢松柏醇(6)、二氢阿魏酸(7)、松柏醛-4-O-β-D-吡喃葡萄糖苷(8)、4-烯丙基-2,6-二甲氧-苯基葡萄糖苷(9)、erythrosyringoylglycerol-4-O-β-D--glucopyranoside(10)、3,4,5-trihydroxyallylbenzene-3-O-β-D--glucopyranosyl-4-O-β-D--glucopyranoside(11)、(7S,8R)syringylglycerol-8-O-4′-sinapyl ether 4-O-β-D-glucopyranoside(12)、3,4-二羟基-5-甲氧基苯甲醛(13)、对羟基苯甲酸(14)、5-hydroxylated isobenzofuran-1(3H)-one(15)、3,5-二甲氧基-4-羟基-苯甲醛(16)、4-羟基-3-甲氧基苯甲醛(17)、3,4,5-trimethoxyphenol-1-O-β-D-glucopyranoside(18)、天麻苷(19)、丁香脂素(20)、丁香脂素-4-O-β-D-葡萄糖苷(21)、丁香脂素-4,4′-O-β-D-二葡萄糖苷(22)、柚皮素(23)、2,6-二甲氧基对苯醌(24)、5-羟甲基糠醛(25)、tetrahydro-5-oxo-2-furancarboxylic acid methyl ester(26)、焦谷氨酸甲酯(27)、川芎哚(28)和尿嘧啶核苷(29)。其中化合物5~1921~29位为首次从该植物中分离得到,化合物810111516182628为首次从石斛属中分离得到。

关键词: Dendrobium huoshanense, chemical constituents, bibenzyl, phenylpropanoid

Abstract:

To investigate the chemical constituents of Dendrobium huoshanense Tang et Cheng.29 compounds were isolated from this plant by multiple column chromatography,such as silica gel,Sephadex LH-20,MCI gel,Rp-18 and semi-preparation HPLC,their structures were elucidated by means of extensive spectroscopic analysis and identified as follows:4,4′-dihydroxy-3,5-dimethoxybibenzyl (1),batatasin III (2),5,4′-dihydroxy-3-methoxybibenzyl (3),dihydroconiferyl dihydrop-hydroxycinnamate (4),methyl 3-propionate (5),dihydroconiferyl alcohol (6),dihydroferulic acid (7),4-O-β-D-glucopyranosyl coniferyl aldehyde (8),4-allyl-2,6-dimethoxyphenyl glucopyranoside (9),erythrosyringoylglycerol-4-O-β-D-glucopyranoside (10),3,4,5-trihydroxyallylbenzene-3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranoside (11),(7S,8R)-syringylglycerol-8-O-4′-sinapyl ether 4-O-β-D-glucopyranoside (12),3,4-dihydroxy-5-methoxybenzaldehyde (13),p-hydroxybenzoic acid (14),5-hydroxylated isobenzofuran-1(3H)-one (15),3,5-dihydroxy-4-hydroxy benzaldehyde (16),4-hydroxy-3-methoxybenzaldehyde (17),3,4,5-trimethoxyphenol-1-O-β-D-glucopyranoside (18),gastrodin (19),(+)-syringaresinol (20),(+)-syringaresinol-4-O-β-D-glucopyranoside (21),liriodendrin (22),naringenin (23),2,6-dimethoxy-p-benzoquinone (24),5-hydroxymethyl furfural (25),tetrahydro-5-oxo-2-furancarboxylic acid methyl ester (26),methyl pyroglutamate (27),periloyrine (28) and uridine (29).Compounds 5-19,21-29 were isolated from this plant for the first time and 8,10,11,15,16,18,26,28 were isolated from this genus.

Key words: Dendrobium huoshanense, chemical constituents, bibenzyl, phenylpropanoid

中图分类号:  Q939.97