天然产物研究与开发 ›› 2022, Vol. 34 ›› Issue (10): 1794-1801.doi: 10.16333/j.1001-6880.2022.10.018

• 综述 • 上一篇    下一篇

基于肠道菌群探讨多糖干预2型糖尿病的研究进展

唐志雁1,2，袁平川1,2,3，柳春燕1,2,3，王国栋1,2,3*   

  1. 1皖南医学院药学院药物研发中心；2安徽省多糖药物工程技术研究中心 安徽省皖南地区植物药活性物质筛选与再评价工程实验室；3活性生物大分子研究安徽省重点实验室，芜湖 241002
  • 出版日期:2022-10-28 发布日期:2022-10-31
  • 基金资助:
    安徽省自然科学基金（1908085MH248）；安徽省高校自然科学研究重大项目（KJ2021ZD0101）

Research progress of polysaccharides intervention in type 2 diabetes mellitus based on gut microbiota

TANG Zhi-yan1,2,YUAN Ping-chuan1,2,3,LIU Chun-yan1,2,3,WANG Guo-dong1,2,3*   

  1. 1Drug Research & Development Center,School of Pharmacy,Wannan Medical College;2Anhui Provincial Engineering Research Center for Polysaccharide Drugs,Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui;3Anhui Province Key Laboratory of Active Biological Macromolecules,Wuhu 241002,China
  • Online:2022-10-28 Published:2022-10-31

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摘要： 2型糖尿病（T2DM）以持续性高血糖为主要特征，发病机制复杂。研究发现肠道菌群的紊乱可减少短链脂肪酸的生成、影响胆汁酸和支链氨基酸的正常代谢以及干扰脂多糖分泌等，从而诱发胰岛素抵抗以及慢性炎症，逐渐发展成为T2DM。多糖由十个及以上的单糖通过糖苷键连接而成，对肠道微生态具有积极的调节作用，可改善肠道菌群功能，维持肠道菌群平衡，改善T2DM肠道菌群紊乱引起的一系列代谢紊乱，从而减少胰岛素抵抗并达到控制血糖的目的。本文综述了肠道菌群及其代谢物在2型糖尿病中的作用；多糖与肠道菌群的相互作用对2型糖尿病的影响。以期为多糖治疗2型糖尿病提供新的思路。

关键词: 2型糖尿病, 肠道菌群, 多糖, 胰岛素抵抗

Abstract:

Type 2 diabetes mellitus (T2DM),with complex and unintelligible pathogenesis,is mainly characterized by persistent high levels of blood glucose.Studies have demonstrated that the disorder of the gut microbiota will lead to a decrease of short-chain fatty acids,affect the metabolism of bile acids,branched-chain amino acids and lipopolysaccharide secretion,so as to induce insulin resistance and chronic inflammation and gradually develop into T2DM.Polysaccharides,which have a positive regulatory effect on the intestinal microecology,are polymer compounds made up of more than ten monosaccharides connected by glycosidic bonds.They can improve the function of gut microbiota,maintain the balance of gut microbiota,and improve a series of metabolic disorders caused by intestinal flora disorders in T2DM,thus reducing insulin resistance and achieving glycemic control.This article reviews the influence of gut microbiota on T2DM and the effect of polysaccharide-gut microbiota interaction on type 2 diabetes mellitus,so as to provide new ideas for the treatment of T2DM with polysaccharides.

Key words: type 2 diabetes mellitus, gut microbiota, polysaccharides, insulin resisitance

中图分类号:  R285

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