天然产物研究与开发 ›› 2022, Vol. 34 ›› Issue (8): 1345-1351.doi: 10.16333/j.1001-6880.2022.8.010

• 研究简报 • 上一篇    下一篇

天山假狼毒的化学成分研究

何晓艳1,2，李小万3，邱远金2，张   晶1*，石磊岭2*   

  1. 1吉林农业大学中药材学院，长春 130118；2新疆维吾尔自治区中药民族药研究所，乌鲁木齐 830002；3新疆农业职业技术学院生物科技分院，昌吉 83110
  • 出版日期:2022-08-28 发布日期:2022-09-08
  • 基金资助:
    国家自然科学基金（81860759）

Chemical constituents from the Stelleropsis tianschanica

HE Xiao-yan1,2,LI Xiao-wan3,QIU Yuan-jing2,ZHANG Jing1*,SHI Lei-ling2*   

  1. 1College of Chinese Medicine Material,Jilin Agricultural University,Changchun 130118,China;2Xinjiang Institute of Chinese and Ethnic Medicine,Urumqi 830002,China;3Xinjiang Agricultural Vocational and Technical College Biological Technology Branch, Changji 831100,China
  • Online:2022-08-28 Published:2022-09-08

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摘要：

研究天山假狼毒Stelleropsis tianschanica的化学成分。运用柱色谱的方法对其进行分离纯化，结合波谱技术与理化性质鉴定化合物结构。本文共从天山假狼毒95%甲醇提取物中分离得到了15个化合物，其中二萜类3个、苯丙素类4个、酚酸类4个、其他类化合物4个，分别鉴定为excoecariatoxin（1）、12-羟基瑞香毒素（2）、2，5-二甲氧基对苯醌（3）、rutamontine（4）、scorpinone（5）、dihydrosyringenin（6）、N-苯乙基乙酰胺（7）、松脂醇（8）、马台树脂醇（9）、vesiculosin（10）、threo-8S-7-methoxysyringylglycerol（11）、cyclo(D)-pro-(D)-leu（12）、threo-3-(4-hydroxy-3,5-dimethoxyphenyl)-3-ethoxypropane-1,2-diol（13）、（-）-丁香素脂酚（14）、threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-［(E)-3-hydroxy-1-propenyl］-2-methoxyphenoxy}-1,3-propanediol（15），其中化合物1~7、12~15均为首次从假狼毒属植物中分离得到。化合物1~15进行细胞毒活性筛选，结果显示化合物1、2、3和10在50 μmol/L时对HGC-27细胞株具有较强的抑制活性，抑制率依次为92.0%、86.8%、87.28%、76.34%。其对HGC-27细胞的IC50值分别为14.06、15.23、17.28、27.1 μmol/L。

关键词: 天山假狼毒, 化学成分, 二萜, 苯丙素类, 12-羟基瑞香毒素

Abstract:

The chemical constituents of Stelleropsis tianschanica were separated and purified by column chromatography,and the structures were identified by spectra analysis combined with physical and chemical properties.Finally,a total of 15 compounds were isolated from 95% methanol extract of  S. tianschanica,including three diterpenoids compounds,four phenylpropanoids compounds,four phenolic acids compounds,and the other four compounds.The structures were identified as excoecariatoxin (1),12-hydroxydaphnetoxin (2),2,5-dimethoxybenzoquinone (3),rutamontine (4),scorpinone (5),dihydrosyringenin (6),N-(2-phenylethyl)acetamide (7),pinoresinol (8),matairesinol (9),vesiculosin (10),threo-8S-7-methoxysyringylglycerol (11),cyclo(D)-pro-(D)-leu (12),threo-3-(4-hydroxy-3,5-dimethoxyphenyl)-3-ethoxypropane-1,2-diol (13),(-)-syringaresinol (14),threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-［(E)-3-hydroxy-1-propenyl］-2-methoxyphenoxy}-1,3-propanediol (15).Compounds 1-7,12-15 are isolated from the Stelleropsis genus for the first time.In addition,cytotoxic effects of compounds 1-15 were screened on HGC-27 gastric cancer cell lines.The results showed that compounds 1,2,3 and 10 were in the range of 50 μmol/L had strong inhibitory activity,and the inhibition rates were 92.0%,86.8%,87.28% and 76.34%,respectively,and their IC50 values were 14.06,15.23,17.28,27.1 μmol/L.

Key words: Stelleropsis tianschanica , chemical composition, diterpenoids, phenylpropanoids, 12-hydroxydaphnetoxin

中图分类号:  R284.2

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