天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (11): 2007-2014.doi: 10.16333/j.10016880.2019.11.022

• 综述 • 上一篇    下一篇

合成微生物群落共培养研究概况

张鑫1,梁建东1*,田维毅1,梁宗琦2   

  1. 1贵州中医药大学基础医学院;2贵州大学真菌资源研究所,贵阳 550025
  • 出版日期:2019-11-28 发布日期:2019-12-16
  • 基金资助:

    贵州省科技基金(黔科合基础[2018]1014);贵州省千层次人才项目2014;贵州省普通高等学校工程研究中心(黔教合KY字[2015]337);贵州省国内一流建设学科(中药学)项目(GNYL[2017]008)

Study profile on coculture of synthetic microbial community

ZHANG Xin1,LIANG Jiandong1*,TIAN Weiyi1,LIANG Zongqi2   

  1. 1College of Basic Medicine,GuiZhou University of Traditional Chinese Medicine;2 Institute of Fungus Resources,Guizhou University,Guiyang,550025,China
  • Online:2019-11-28 Published:2019-12-16

摘要:  合成微生物群落的共培养是在一个培养容器中一起培养两种或多种微生物的方法,通过模拟自然生态,来构建人工的微生物群落,可导致现有天然产物积累的增加,或由于微生物串扰和化学防御而触发沉默生物合成途径的表达,产生新的化合物。本文从合成微生物群落的共培养体系及应用等方面对国内外有关合成微生物群落共培养的研究进行概述,旨在为合成微生物群落共培养的进一步深入研究及开发应用提供参考。

关键词: 共培养, 合成微生物群落, 发酵, 代谢组学

Abstract: Coculture of synthetic microbial community was a method of culturing two or more microorganisms together in a culture container,Through the simulation of natural ecology,to build artificial microbial community,it could lead to an increase in the accumulation of existing natural products,or trigger the expression of silenced biosynthesis pathways due to microbial crosstalk and chemical defense to produce new compounds.This review introduced the coculture system and application of synthetic microbial community,worth further studying and exploring.

Key words: coculture, synthetic microbial community, fermentation, metabolomics

中图分类号: 

Q93