天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (12): 2132-2141.doi: 10.16333/j.1001-6880.2020.12.019

• 综述 • 上一篇    下一篇

中药抗结直肠癌的作用机制研究进展

李变丽1,2,3,4,陈华国1,2,3,赵超1,2,3,周欣1,2,3*   

  1. 1贵州师范大学 贵州省山地环境信息系统与生态环境保护重点实验室;2贵州师范大学 喀斯特山地生态环境保护与资源利用协同创新中心;3贵州师范大学 贵州省药物质量控制及评价技术工程实验室,贵阳 550001;4贵州中医药大学,贵阳550002

  • 出版日期:2020-12-28 发布日期:2020-12-25
  • 基金资助:
    贵州省高层次创新人才培养项目(黔科合人才(2015)4033号);贵州省优秀青年科技人才项目(黔科合平台人才[2017]5625)

Research progress on the mechanism of Chinese medicine against colorectal cancer

LI Bian-li1,2,3,4,CHEN Hua-guo1,2,3,ZHAO Chao1,2,3,ZHOU Xin1,2,3*   

  1. 1Guizhou Normal University Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment;
    2Guizhou Normal University Collaborative Innovation Center for Karst Mountain Ecological Environment Protection and Resource Utilization (Project of Education Department of Guizhou Province);3Guizhou Normal University Guizhou Provincial Laboratory of Drug Quality Control and Evaluation Technology,Guiyang 550001,China;4Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China

  • Online:2020-12-28 Published:2020-12-25

摘要: 结直肠癌是常见的消化道恶性肿瘤之一,发病率和病死率较高,严重威胁人类的正常生活。中药治疗结直肠癌具有高效、毒副作用小的特点,近年来已成为结直肠癌的有效治疗方法。本文系统总结了中药复方、提取物、单体化合物抗结直肠癌的作用机制,如诱导细胞凋亡、抑制癌细胞增殖、阻滞细胞周期等。并在此基础上分析了中药治疗结直肠癌的研究现状,以期为新型抗结直肠癌的中药药剂的研发提供参考依据。


关键词: 结直肠癌, 中药, 作用机制, 研究现状

Abstract:

Colorectal cancer is one of the most common digestive tract cancers with high morbidity and mortality,which seriously threaten human's normal life.With the development in recent years,traditional Chinese medicine has become an effective method for the treatment of colorectal cancer.This paper systematically summarized the anti-colorectal cancer mechanism of Chinese herbal formula,extract and monomer compound,such as inducing cell apoptosis,inhibiting cancer cell proliferation and blocking cell cycle,etc.Furthermore,the research status of traditional Chinese medicine in the treatment of colorectal cancer was analyzed,which could provide reference for the development of new anti-colorectal traditional Chinese medicine.

Key words: colorectal cancer, traditional Chinese medicine, mechanism, research status 

中图分类号:  R932