NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (11): 1830-1837.doi: 10.16333/j.1001-6880.2016.11.026

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Review on Development of New Camptothecin Derivatives as Antitumor Agents

ZHANG Lei,ZHANG Ze-guo,WANG Jing*   

  1. School of Pharmacy,Zunyi Medical College,Zunyi 563003,China
  • Online:2016-11-30 Published:2017-03-30

Abstract: Camptothecin is an important antitumor product from Camptotheca acuminata, however,the disadvantages,such as poor solubility,toxicity and metabolic inactivation,block its application as antineoplastic agent.Over the past few decades,the modifications of camptothecin have been carried out by numerous researchers to conquer its drawbacks,and many excellent camptothecin derivatives were developed,including topotecan and irinotecan.This review will highlight recent advances (2013-2016) in the development of new camptothecin derivatives as potential anticancer agents.

Key words: camptothecin, derivatives, anticancer

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