Naringenin has better antioxidant activity.However,its application is limited due to its low bioavailability.In this article,13 kinds of naringenin acylhydrazone derivatives were synthesized,12 of them have not been reported in the literature.The antioxidant activities in vitro of 13 derivatives were determined by ABTS,FRAP,and DPPH methods.The results show that the antioxidant activity of 13 compounds is stronger than that of naringenin,and the antioxidant activity of 8 derivatives is 3 to 6 times higher than that of naringenin.In the cytotoxicity test,when the cell survival rate is >90%,it is regarded that the compound does not inhibit the cells.When the concentration range of 0-25 mol/L,the survival rate of HEK293 cells treated with derivatives b,g,j,k and l was more than 90%.In addition,when the concentration of derivatives g,k,l is 0-50 μmol/L,the survival rate of HEK293 cells is still more than 90%.Especially when the concentration of derivative j is as high as 100 μmol/L,the cell survival rate was still above 90%.The results provide a theoretical basis for the later screening of antioxidant food additives and antioxidant drugs.