NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2022, Vol. 34 ›› Issue (4): 598-605.doi: 10.16333/j.1001-6880.2022.4.007

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Study on chemical constituents and antibacterial activity of Carpesium faberi

CHEN Jie1,WANG Dan1,ZHANG Xiong1,PENG Ming-you1,XU Ran1,2,YAN Ying1,2,WANG Ying1,2*   

  1. 1College of Pharmacy,Guizhou Medical University,Guiyang 550025,China;2Engineering Technology Research Center for Chemical Drug R&D,Guizhou Medical University,Guiyang 550004,China
  • Online:2022-04-29 Published:2022-04-29

Abstract:

In order to study the chemical composition and antibacterial activity of Carpesium faberi, 14 compounds were obtained from the ethanol extract of C. faberi by applying various chromatographic techniques.Their structures were elucidated and identified as granilin (1),4α,10α-dihydroxy-1βH,5βH-guai-11(13)-en-12,8α-olide (2),4β,10β-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide (3),4-epi-isoinuviscolide (4),11(13)-dehydroivaxillin (5),carabrone (6),vomifoliol (7),cassipourol (8),4′,5′-dehydrodiodictyonema A (9),(3R)-8-Hydroxylinalool (10),cholest-7-en-3β-ol (11),stigmasterol (12),5,8-epidioxy-5α,8α-ergosta-6,22E-dien-3β-ol (13),stigmasta-5,22-diene-3β,7α-diol (14).Among them,compounds 2 and 7-14 were obtained from this plant for the first time.The antibacterial activity of compounds 1-14 was preliminarily evaluated,and compound 1 showed weak activity against Bacillus subtilis;compounds 6 and 10 showed weak activity against Candida albicans.

Key words: Carpesium faberi, chemical constituents, isolation and identification, antibacterial activity

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