NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2022, Vol. 34 ›› Issue (5): 836-841.doi: 10.16333/j.1001-6880.2022.5.012

Previous Articles     Next Articles

Mechanism of improving learning and memory in Alzheimer’s disease model rats by Angelica volatile oil

WANG Hu-ping1,2*   

  1. 1Gansu University of Chinese Medicine;2Key Laboratory of Traditional Chinese Herbs Discovery and Innovation and Transformation in Gansu Province,Lanzhou 730000,China
  • Online:2022-05-28 Published:2022-05-23

Abstract:

This study aims to explore the effect and mechanism of Angelica volatile oil on learning and memory in Alzheimer’s disease (AD) model rats.The rats were divided into 6 groups:sham operation group,model group,positive group and low,medium and high dose groups of Angelica volatile oil.Brain stereotactic injection of Aβ25-35 was used to establish AD rat model and the drugs were administered by gavage.The learning and memory ability of rats was examined by Morris water maze.Serum acetylcholine (ACh),activity of choline acetyltransferase (ChAT) and β-amyloid precursor protein(APP),amyloid β-protein 1-42 (Aβ1-42) in hippocampus were detected by ELISA.The levels of superoxide dismutase (SOD),malondialdehyde (MDA) and acetylcholinesterase (AChE) were measured by colorimetry.The results showed that Angelica volatile oil could improve the learning and memory ability of AD model rats,increase the activities of Ach,chat and SOD (P < 0.05),and reduce serum AChE,the level of MDA and content of hippocampus APP and Aβ1-42(P < 0.05).The results show that Angelica volatile oil can effectively improve the learning and memory ability of AD model rats and has preventive and therapeutic effect on AD,which may be related to the regulation of cholinergic neurotransmitter,free radical oxidation and Aβ metabolism.

Key words: Angelica volatile oil, Alzheimer’s disease, learning and memory of ability, mechanism research

CLC Number: