关键词: 奶子藤, 吲哚生物碱, 生物活性, 化学成分

Abstract: In order to investigate the chemical constituents and biological activities of Bousigonia mekongensis,nine compounds were isolated from the roots of B. mekongensis by repeated column chromatography over silica gel,RP-18 and preparative-HPLC.On the basis of NMR and MS spectroscopic analysis,their structures were identified as quebrachamine (1),(-)-isoeburnamine (2),rhazinilam (3),tetrahydroalstonine (4),leuconodine D (5),leucophyllidine (6),(-)-O-ethyleburnamine (7),(-)-ebumamenine (8),eburenine (9),respectively.Compound 1 and 3-7 were obtained from this genus for the first time,and compound 2 was isolated from this plant for the first time.All compounds were evaluated the activities of preventing high glucose-induced podocyte injury and inhibiting of amyloid-β.Compound 6 exhibited moderate Aβ inhibitory activity (IC₅₀= 26.1 μM),other compounds showed no activity.

Key words: Bousigonia mekongensis, indole alkaloids, bioactivity, chemical constituents