天然产物研究与开发 ›› 2025, Vol. 37 ›› Issue (5): 983-991.doi: 10.16333/j.1001-6880.2025.5.019 cstr: 32307.14.1001-6880.2025.5.019

• 综述 • 上一篇    

基于cGAS-STING信号通路探讨中药活性成分抗肿瘤机制研究进展

王可雅1，亓俊伟1，张 彤2，李 笑3*   

  1. 1山东中医药大学医学院；2山东中医药大学眼科与视光医学院；3山东中医药大学中医学院，济南 250355
  • 出版日期:2025-05-28 发布日期:2025-05-26
  • 基金资助:
    山东省中医药科技项目(M-2023005)；2023年度山东省医药卫生科技项目(202313051718)

Research progress on the anti-tumor mechanism of active ingredients in traditional Chinese medicine based on the cGAS-STING signaling pathway

WANG Ke-ya1,QI Jun-wei1,ZHANG Tong2,LI Xiao3*   

  1. 1College of Medicine,Shandong University of Traditional Chinese Medicine;2College of Ophthalmology and Optometry,Shandong University of Traditional Chinese Medicine;3College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China
  • Online:2025-05-28 Published:2025-05-26

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摘要：

环磷酸鸟苷-腺苷合成酶（cyclic guanosine monophosphate-adenosine monophosphate synthase，cGAS）-干扰素基因刺激因子（stimulator of interferon genes，STING）信号通路是一种新型的免疫应答的信号通路，调控肿瘤发展的多种生物学行为。在肿瘤发生时，该信号通路被异常的DNA激活，进一步耦联STING蛋白释放I型干扰素发挥其强大的免疫作用。研究发现，cGAS-STING信号通路的激活不仅具有抗肿瘤效应，同时还有一定的促瘤作用。基于该信号通路对肿瘤的双重作用，越来越多的研究者发现中药单体可以通过干预通路的方式在肿瘤发生的不同阶段抑制肿瘤的恶化，展现中医药在肿瘤治疗方面独特的优势。因此本文系统地阐述了cGAS-STING信号通路对肿瘤的作用机制，并就近十年来中药单体活性成分基于cGAS-STING信号通路对肿瘤的治疗进行了全面的分析探讨，以便进一步研究中药及其有效成分在cGAS-STING信号通路的作用机制，以期为临床研究新药物提供思路。

关键词: cGAS-STING信号通路, 抗肿瘤, 免疫应答, 中药单体活性成分, 作用机制, 中医药发展

Abstract:

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING)signaling pathway is a novel immune response signaling pathway that regulates various biological behaviors of tumor development. During tumor development, this signaling pathway is activated by abnormal DNA, further coupling with STING protein to release type I interferon and exert its powerful immune effect. Research has found that the activation of the cGAS-STING signaling pathway not only has anti-tumor effects, but also has a certain pro tumor effect. Based on the dual effects of this signaling pathway on tumors, more and more researchers have found that traditional Chinese medicine monomers can inhibit tumor progression at different stages of tumor development by intervening in the pathway, demonstrating the unique advantages of traditional Chinese medicine in tumor treatment. Therefore, this article systematically elaborates on the mechanism of action of the cGAS-STING signaling pathway on tumors, and comprehensively analyzes and explores the treatment of tumors based on the cGAS-STING signaling pathway by active ingredients of traditional Chinese medicine monomers in the past decade, in order to further study the mechanism of action of traditional Chinese medicine and its active ingredients in the cGAS-STING signaling pathway, and provide ideas for clinical research of new drugs.

Key words: cGAS-STING signaling pathway, anti tumor, immune response, active ingredients of traditional Chinese medicine monomers, mechanism of action, development of traditional Chinese medicine

中图分类号:  R285

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