天然产物研究与开发 ›› 2025, Vol. 37 ›› Issue (增刊1): 151-161.

• 综述 • 上一篇    下一篇

中医药治疗结直肠癌肝转移的理论与机制研究进展

李  楠1,2，张  策1*，郝淑兰2*   

  1. 1山西医科大学细胞生理学教育部重点实验室，太原 030001；2山西省中医药研究院肿瘤科，太原 030012
  • 出版日期:2025-09-25 发布日期:2025-09-22
  • 基金资助:
    国家科技重大专项（2023ZD0502905）;山西省中央引导地方科技（YDZJSX20231C020）；山西省医学重点科研项目-重大科技攻关专项（2022XM10）

Research progress on theory and mechanism of traditional Chinese medicine in treating colorectal cancer liver metastases

LI Nan1,2,ZHANG Ce1*,HAO Shu-lan2*   

  1. 1Key Laboratory of Cellular Physiology at Shanxi Medical University,Ministry of Education,Taiyuan 030001,China;2Shanxi Provincial Research Institute of Traditional Chinese Medicine,Taiyuan 030012,China
  • Online:2025-09-25 Published:2025-09-22

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摘要：

结直肠癌是全球三大常见恶性肿瘤之一，肝脏是其最常见的转移部位，而且肝转移是结直肠癌患者死亡的主要原因。除了手术治疗外，西医学主要采用化疗、射频消融、免疫治疗和靶向治疗等手段。然而，这些治疗方法在延长患者生存时间的同时，也伴随着显著的不良反应，导致患者的生活质量下降。相比之下，中医药凭借其多成分、多靶点和多途径的特点，在治疗结直肠癌肝转移（colorectal cancer liver metastasis，CRLM）方面展现出潜力。多项研究表明，中医药干预不仅有助于延长CRLM患者的生存期，还能够缓解症状，改善患者的生活质量。并且多项现代研究了中医药，包括中药以及中药提取物的作用机制，为新药的研发提供了基础。本文将综述中医学对CRLM的认识与理解，并探讨中医药在CRLM治疗中的作用机制。

关键词: 结直肠癌, 肝转移, 中医, 作用机制, 药理机制

Abstract:

Colorectal cancer (CRC) is one of the three most common malignant tumors worldwide,with the liver being the primary site of metastasis.Liver metastasis is also the leading cause of death in CRC patients.In addition to surgical treatment,Western treatments primarily employs chemotherapy,radiofrequency ablation,immunotherapy,and targeted therapy.While these approaches can extend survival,they are often associated with substantial adverse effects that impair patients' quality of life.Traditional Chinese medicine (TCM),characterized by its multi-component,multi-target,and multi-pathway effects,has demonstrated therapeutic potential in colorectal cancer liver metastasis (CRLM).Multiple studies have indicated that TCM intervention not only helps extend the survival of CRLM patients but also alleviates symptoms and enhances their quality of life.Moreover,modern pharmacological studies have elucidated the mechanisms of action of TCM,including its active compounds,providing a foundation for novel drug development.This article will review the understanding and interpretation of CRLM within the framework of Traditional Chinese Medicine theory,and discuss the mechanisms through which TCM acts in the treatment of CRLM.

Key words: colorectal cancer, liver metastasis, traditional chinese medicine, mechanism of action, pharmacological mechanism

中图分类号:  R273

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