河南鼠尾草抑制体内外α-糖苷酶活性研究

doi:A

天然产物研究与开发 ›› 2012, Vol. 23 ›› Issue (4): 533-535.doi: A

河南鼠尾草抑制体内外α-糖苷酶活性研究

闫文艺^1,2，曹乃锋²，张倩²，康文,2^*

¹河南大学中药研究所，河南开封 475004；²河南大学研究生院，河南开封 475004

收稿日期:2010-01-15 出版日期:2012-04-26 发布日期:2012-05-16
基金资助:
河南省教育厅青年骨干教师资助计划（教高2008-755）

α-Glucosidase Inhibitory Activity of Salvia honania L.H.Bailey in vivo and vitro

YAN Wen-yi^1,2,CAO Nai-feng², ZHANG Qian², KANG Wen-yi^2*

¹ Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China; ² The graduate school of Henan University, Kaifeng, 475004, China

Received:2010-01-15 Online:2012-04-26 Published:2012-05-16

摘要/Abstract

摘要： 本文采用96微孔板法，首次对河南鼠尾草抑制酵母和大鼠小肠α-葡萄糖苷酶活性进行研究。河南鼠尾草乙酸乙酯提取物(IC50=28.73 μg/mL)和正丁醇提取物(IC50=73.90 μg/mL) 抑制酵母α-葡萄糖苷酶活性远高于阳性对照Acarbose (IC50=1081.27 μg/mL)，但只有乙酸乙酯提取物(IC50=366.79 μg/mL)具有抑制大鼠小肠α-葡萄糖苷酶活性，阳性对照Acarbose未检测出其IC50。结果表明，河南鼠尾草乙酸乙酯提取物和正丁醇提取物均具有较好的酵母α-葡萄糖苷酶抑制活性，但只有乙酸乙酯提取物具有良好的大鼠小肠α-葡萄糖苷酶抑制活性。

关键词: 河南鼠尾草；酵母&alpha, -葡萄糖苷酶；大鼠小肠&alpha, -葡萄糖苷酶；抑制活性

Abstract: The yeast and rat intestinal α-glucosidase inhibitory activity of Salvia. honania was assayed by the method of 96-microplates for the first time. Yeast α-glucosidase inhibitory activity of ethyl acetate extracts (IC50 =28.73 μg/mL) and n-butanol extracts of S. honania (IC50 =73.90 μg/mL) were higher than that of Acarbose (IC50=1081.27 μg/mL) as positive control. Only ethyl acetate extracts (IC50 =366.79 μg/mL) showed inhibitory activity on rat intestinal α-glucosidase, and the IC50 value of Acarbose was not detected. The results indicated that both ethyl acetate extracts and n-butanol extracts of S. honania showed a better yeast α-glucosidase inhibitory activity, but only ethyl acetate extracts showed a better rat intestinal α-glucosidase inhibitory activity.

Key words: Salvia honania L.H.Bailey, yeast α-glucosidase, rat intestinal α-glucosidase, inhibitory activity

中图分类号:

Q946.81

闫文艺，曹乃锋，张倩，康文艺. 河南鼠尾草抑制体内外α-糖苷酶活性研究[J]. 天然产物研究与开发, 2012, 23(4): 533-535.

YAN Wen-yi,CAO Nai-feng, ZHANG Qian, KANG Wen-yi. α-Glucosidase Inhibitory Activity of Salvia honania L.H.Bailey in vivo and vitro [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(4): 533-535.

参考文献 1

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河南鼠尾草抑制体内外α-糖苷酶活性研究

α-Glucosidase Inhibitory Activity of Salvia honania L.H.Bailey in vivo and vitro

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