乳酸菌的降血糖作用研究进展

doi:A

摘要/Abstract

摘要： 目前乳酸菌的防治糖尿病功效已得到广泛认可。本文综述国内外关于乳酸菌应用于临床糖尿病治疗的研究进展，对乳酸菌可能的降血糖作用机理及物质基础进行了分析总结，并对目前存在的安全性问题和今后研究方向进行探讨, 希望为糖尿病防治提供新的思路，为开发新型降糖药物提供一定的理论依据。

关键词: 乳酸菌, 糖尿病, 降血糖, 作用机制

Abstract: Hypoglycemic activities of many kinds of lactic acid bacteria have been proved．The article summarized current clinical applications and the research progress on hypoglycemic activity of lactic acid bacteria, and their hypoglycemic mechanism and bioactive compounds were analyzed. The safety and the future direction of research in this field were also discussed. The results of this study provided reference for exploiting new hypoglycemic drug from lactic acid bacteria for the treatment of diabetes.

Key words: lactic acid bacteria, diabetes mellitus, hypoglycemic activity, mechanism

中图分类号:

R284.2

范文娅，吴正钧，郭本恒. 乳酸菌的降血糖作用研究进展[J]. 天然产物研究与开发, 2012, 23(09): 1323-.

FAN Wen-ya, WU Zheng-jun, GUO Ben-heng. Research Advances in Hypoglycemic Activity of Lactic Acid Bacteria[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(09): 1323-.

参考文献

1 Guo BH(郭本恒).Probiotics.Beijing:Chemical Industry Press,2004:61-62.
2 Yun SI,et al.Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes.Appl Microbiol,2009,107:1681-1686.
3 Yadav H,et al.Effect of probiotic dahi containing lactococcus lactis on the progression of diabetes induced by a high fructose diet in rats.Biosci Biotechnol Biochem,2006,70:1255-1258.
4 Watts T,et al.Role of the intestinal tight junetion modulator zonulin in the Pathogenesis of type1diabetes in BB diabetic-prone rats.Proc Natl Acad Sci USA,2005,102:2916-2921.
5 Dumas ME.Metabolic profiling reveals a contribution of gut mierobiota to fatty liver phenotype in insulin-resistant mice.Proc Natl Acad Sci USA,2006,103:12511-12516.
6 Neal MD,et al.Enteroeyte TLR4 mediates phagocytosis and translocation of baeteria across the intestinal barrier.J Immunol,2006,176:3070-3079.
7 Bie MJ(别明江),LIU X(刘祥).Study on the relationship between the blood sugar levels and microflora in diabetic mouse model.Mod Prev Med(现代预防医学),2005,32:1441-1443.
8 Ewaschuk JB,et al.Surface expression of Toll-like receptor 9 is up regulated on intestinal epithelial cells in response to pathogenic bacterial DNA.Infect Immun,2007,75:2572-2579.
9 Van GA,et al.Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii,LA1) on early endoscopic recurrence of Crohn′s disease after ileo-caecal resection.Inflamm Bowel Dis,2007,13:135-142.
10 Michail S,Abernathy F.Lactobacillus plantarum inhibits the intestinal epithelial migration of neutrophils induced by enteropathogenic Escherichia coli.J Pediatr Gastroenterol Nutr,2003,36:385-391.
11 Huang H(黄回),Han CM(韩春茂).Effects of Lactobacillus ecological immune nutrition in maintaining bowel mucosa barrier.Chin J Burns(中华烧伤杂志),2005,21:155-157.
12 Calcinaro F.Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse.Diabetologia,2005,48:1565-75.
13 Matsuzaki T.Antidiabetic effects of an oral administration of Lactobacillus casei in a non –insulin-dependent diabetes mellitus(NIDDM)model using KK-AY mice.Endocr J,1997,44:357-65.
14 Gronlund MM,et al.Importance of interstin colonization in the maturation of humoral immunity in early infaney:prospective follow-up study of healthy infants aged 0-6 months.Arch Dis Child,2000,83:186-192.
15 Freitas M,et al.Host-pathogens crosstalk Indigenous bacteria and probiotics also play the game.Biol Cell,2003,95:503-506.
16 Galdeano C M,et al.Proposed model:mechanisms of immunomodulation induced by probiotic bacteria.Clin Vaccine Immunol,2007,14:485-492.
17 Cross ML.Microbes versusm icrobes immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens.FEMS Immunol Med Microbiol,2002,34:245-248.
18 Feinstein R,et al.Tumor necrosis factor-a suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.J Biol Chem,1993,268:26055 -26058.
19 Mandrup PT,et al.Cytokines and free radicals as effector molecules in the destruction of pancreatic D-cells.Curr Top Microbiol Immunol,1990,164:169-193.
20 Hotamisligil GS,et al.Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes.Central role of tumor necrosis factor-a.J Clin Invest,1994:1543 -1549.
21 Del RA,Besedovsky H.Antidiabetic effects of interleukin 1.Pro Natl Acad Sci,1989:5943-5949.
22 Maritim AC,et al.Diabetes,oxidative stress and antioxidant:a review.J Biochem Mol Toxical,2003,17:24-38.
23 Fang M(方明),et al.The control of Ⅱdiabetes blood and correlation analysis of oxidative stress,NO,CRP.Zheiiang J Integr Tradit Chin West Med(浙江中西医结合杂志),2008,18:87-88.
24 Li XL(李晓林),et al.The content changes of SOD and MDAin important organic tissues of adult diabetic rat.Chin J Gerontol (中国老年学杂志),2005,25:412-413.
25 Lapidot T,et al.Antioxidant and prooxidant effects of phenolics on pancreatic β-cells in vitro.J Agric Food Chem,2002,50:7220-7225.
26 26.Evans JL,et al.Are oxidative stress-activated signaling pathway smediators of insulin resistanceand beta-celldysfunction? Diabetes,2003,52(1):1-8.
27 Maritim AC,et al.Diabetes Oxidative stress and anfiofidants:A review.J Biochem Mol Toxicol,2003,17:24-37.
28 Jeongmn L,et al.Resistance of Lactobacillus casei KCTC 3260 to reactive oxygen species (ROS):role for a metal ion chelating effect.J Food Sci,2005,70:388-391.
29 Meng HBLG(孟和毕力格),et al.Antioxidative effect of Lactobacillus MG2-1 in Koumiss.Chin Dairy Ind(中国乳品工业),2005,33:24-29.
30 Yadav H,et al.Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats.Nutr,2007,23:62-68.
31 Willcox J K,et al.Antioxidants and prevention of chronic disease.Crit Rev Food Sci Nutr,2004,44:275-295.
32 Li GW(李光伟),Ning G(宁光).Zhou ZG(周智广).Primary intensive insulin therapy improves islet β-cell function in type 2 diabetes A dream or reality?Chin J Endocr Metab(中华内分泌代谢杂志),2006,22:309-312
33 Matsuzaki T,et al.Effect of oral administration of Lactobacillus casei on alloxan-induced diabetes in mice.APMIS,1997,105:637-642.
34 Tabuchi M.Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats.Biosci Biotechnol Biochem,2003,67:1421-1424.
35 Anne.S A,et al.Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects..Br J Nutr,2010,1-8.
36 Kong LF(孔令芳),et al.Influence of chromium trichloride on erythrocytic insulin receptor of patients with type 2 diabetes mellitus.Chin J Mod Med (中国现代医学杂志),2005,15:3089-3092.
37 Hiroaki M,et al.Effect of an exopolysaccharide(kefiran) form lactobacillus kefiranofaciens on blood glucose in KKAy mice and constipation in SD rats induced by a low-fiber diet.Biosci Microfl,2004,23:149-153.
38 Toshihiko Y,et al.Effects of the probiotic strain Lactobacillus johnsonii strain La1 on autonomic nerves and blood glucose in rats.Life Sci,2006,79:1963-1967.
39 Xu LL(徐灵龙),et al.Research on the inhibitory effect of Lactobacillus against Escherichia coli.J Chin Electr Microsc Soc(电子显微学报),2005,24:17.
40 Levettan C.Oral antidiabetic agents in type 2 diabetes.Curr Med Res Opin,2007,23:945 -952.
41 Chen SW(陈思维),et al.Expression of human insulin in lactic acid bacteria and its oral administration in non-obese diabetic mice.Acta Microbiol Sin(微生物学报),2007,47:987-991.
42 Zein EF,et al.Lactobacillus rhamnosus septicemia in a diabetic patient associated with probiotic use:a case report.Ann Biol Clin (Paris),2008,66:195-198.

[1]	王逸旋, 袁宇, 闵冬雨, 鞠业涛, 孙翠鸽, 胡丽萍. 金丝桃苷对高脂饮食联合链脲佐菌素所致糖尿病肾病小鼠的干预作用[J]. 天然产物研究与开发, 2024, 36(增刊1): 76-83.
[2]	王宁, 戈进. 基于网络药理学及体外实验探讨逍遥丸治疗肝硬化的作用机制[J]. 天然产物研究与开发, 2024, 36(增刊1): 121-132.
[3]	冯超颖, 高璐, 孙梅好, 巩菊芳, 蒲首丞. 基于酶学、网络药理学及分子模拟分析黄芪葛根汤对新冠肺炎合并糖尿病的作用机制[J]. 天然产物研究与开发, 2024, 36(增刊1): 133-146.
[4]	郑志忠, 黄飞, 明艳林, 陈菲. 基于网络药理学和分子对接研究绞股蓝防治糖尿病的作用机制[J]. 天然产物研究与开发, 2024, 36(增刊1): 147-155.
[5]	朱海燕, 杨福权, 左秦川, 房智彦, 黄丽莉, 淮文英, 王艳秋, 张天娥. 基于UPLC-Q-Orbitrap HRMS结合网络药理学探讨半夏泻心汤入血成分及治疗脾虚型溃疡性结肠炎的作用机制[J]. 天然产物研究与开发, 2024, 36(9): 1610-1624.
[6]	张亚伦, 朱研洁, 代向阳, 王小兰, 郝志友, 孙彦君, 冯卫生, 陈辉. 肉桂叶化学成分研究[J]. 天然产物研究与开发, 2024, 36(7): 1142-1148.
[7]	黄丽荣, 余佳, 李娇, 程莎骆衡. 基于网络药理学及实验验证探究苗药虎掌草不同溶剂提取物抗前列腺癌活性及其作用机制[J]. 天然产物研究与开发, 2024, 36(7): 1231-1241.
[8]	马广礼, 夏晓培. 灵芝多糖对糖尿病肾病小鼠的改善作用及机制研究[J]. 天然产物研究与开发, 2024, 36(6): 938-945.
[9]	孙晓娟, 吴安楠, 侯娜, 李娜. 有氧运动和白藜芦醇对糖尿病肾病大鼠肾组织炎症和凋亡的影响[J]. 天然产物研究与开发, 2024, 36(6): 946-953.
[10]	杜雨璇, 谢治深, 徐江雁, 王潘. 鬼箭羽化学成分和药理作用的研究进展及其质量标志物预测[J]. 天然产物研究与开发, 2024, 36(6): 1064-1081.
[11]	宋钰, 纪丽莲, 刘艳丽, 王桃云. 枸骨的化学成分及其药理活性研究进展[J]. 天然产物研究与开发, 2024, 36(6): 1082-1099.
[12]	张露, 程鑫鹏, 邓梅, 陈明舜, 周祺溟, 彭春彦, 谢作桦, 涂宗财. 丹皮乙醇提取物的抗氧化和抗糖尿病活性研究[J]. 天然产物研究与开发, 2024, 36(5): 762-770.
[13]	刘玉斌, 苏金浩, 陈伟, 王军, 及晓晖, 刘英凯, 王元松. 藏红花素调控NLRP3通路抑制上皮间质转化治疗糖尿病肾病的机制研究[J]. 天然产物研究与开发, 2024, 36(4): 589-596.
[14]	赵金诺, 覃怡发, 张轩, 张梦娇, 晏晶晶, 梁皓皓. 华泽兰根化学成分及其抑制α-葡萄糖苷酶和蛋白酪氨酸磷酸酶1B的活性研究[J]. 天然产物研究与开发, 2024, 36(10): 1698-1706.
[15]	邱尉宸, 恽奕轩, 蒋小岗. 海藻糖药理作用研究进展[J]. 天然产物研究与开发, 2024, 36(10): 1813-1819.