沉淀聚合法制备1-脱氧野尻霉素分子印迹聚合物微球及其性能研究

doi:10.16333/j.1001-6880.2015.01.034

天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (1): 169-172.doi: 10.16333/j.1001-6880.2015.01.034

沉淀聚合法制备1-脱氧野尻霉素分子印迹聚合物微球及其性能研究

罗孟君*，邓凤君1，郭巧红1，陈宗高2，陈波3

1 益阳医学高等专科学校，益阳413000；2 益阳市第一中学，益阳 413000；3 湖南师范大学化学化工学院，长沙 410081

出版日期:2015-01-31 发布日期:2015-02-12

Study on the Synthesis and Performance of 1-Deoxynojirimyc in Molecularly Imprinted Polymer Micro-Spheres via Precipitation Polymerization

LUO Meng-jun1*, DENG Feng-jun1, GUO Qiao-hong1, CHEN Zong-gao2, CHEN Bo3

1 Yiyang Medical College,Yiyang 413000,China;2No.1 Middle School of Yiyang,Yiyang 413000,China;3Chemical Engineering of Hunan Normal University,Changsha 410081,China

Online:2015-01-31 Published:2015-02-12

摘要/Abstract

摘要： 本研究制备了1-脱氧野尻霉素分子印迹聚合物微球，考察溶剂、反应时间对分子印迹聚合物产率以及性能的影响。以1-脱氧野尻霉素为模板分子，α-甲基丙烯酸（MAA）为功能单体，乙二醇二甲基丙烯酸酯（EGDMA）为交联剂，采用沉淀聚合法合成分子印迹微球，采用静态吸附及扫描电镜（SEM）的方法对微球进行表征。结果表明，当反应时间为24 h、乙腈为溶剂时，所制得印迹聚合物微球的形貌和吸附性能较好，对1-脱氧野尻霉素与N-甲基-1-脱氧野尻霉素的选择性分离因子α为2.26，说明分子印迹聚合物微球对1-脱氧野尻霉素分子有特异性吸附和识别能力。

关键词: 沉淀聚合法, 分子印迹聚合物, 1-脱氧野尻霉素

Abstract: The 1-deoxynojirimyc molecular imprinted polymer (MIP) microsphere was synthesized in this study.The influences of reaction conditions,including the category of solvent and reaction time on the morphology and adsorption properties of MIP microspheres were studied.1-deoxynojirimyc MIP microspheres were prepared by precipitation polymerization with 1-deoxynojirimyc as template and ethyleneglycol dimethacrylate (EGDMA) as cross-linker.The microspheres were characterized by static adsorption and scanning electron microscopy (SEM).The results showed the reaction time was 24 h,and acetonitrile was the solvent.The 1-deoxynojirimyc MIP microspheres were regular microspheres.The MIP microspheres showed high adsorption capacity and the partition N-methyl-1-deoxynojirimycin of the microspheres adsorbing 1-deoxynojirimyc was 2.26.It showed that 1-deoxynojirimyc MIP microspheres had specific adsorption and recognition capabilities to 1deoxynojirimyc molecules.

Key words: precipitation polymerization, molecular imprinted polymer, 1-deoxynojirimyc, microsphere

中图分类号:

TQ050.4+3

罗孟君*，邓凤君1，郭巧红1，陈宗高2，陈波3. 沉淀聚合法制备1-脱氧野尻霉素分子印迹聚合物微球及其性能研究[J]. 天然产物研究与开发, 2015, 27(1): 169-172.

LUO Meng-jun1*, DENG Feng-jun1, GUO Qiao-hong1, CHEN Zong-gao2, CHEN Bo3. Study on the Synthesis and Performance of 1-Deoxynojirimyc in Molecularly Imprinted Polymer Micro-Spheres via Precipitation Polymerization[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(1): 169-172.

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沉淀聚合法制备1-脱氧野尻霉素分子印迹聚合物微球及其性能研究

Study on the Synthesis and Performance of 1-Deoxynojirimyc in Molecularly Imprinted Polymer Micro-Spheres via Precipitation Polymerization

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