关键词: 连花清瘟胶囊, 化学成分, 木脂素, 蒽醌

Abstract: Seventeen compounds were isolated from the raw material of Lianhua-Qinwen capsule by column chromatographies of silica gel,Sephadex LH-20 and preparative HPLC,which were elucidated by means of IR,MS, ¹H NMR and ¹³C NMR.They were identified as (+)-pinoresinol (1), phillyrin (2), epipinoresinol4′-O-β-D-glucoside (3),matairesinol-4′-O-β-D-glucoside (4),chrysophanol-1-O-β-D-glucoside (5),aloe emodin-8-O-β-D-glucoside (6),chrysophanol (7), emodin (8), physcion (9), aloe-emodin (10), aloe-emodin acetate (11),quercetin-3-O-α-L-rhamnoside (12),kaempferol-3-O-α-L-rhamnoside (13),adoxosidic acid (14),gallic acid (15),benzoic acid (16),and β-sitosterol (17).This was the first time to investigate the chemical basis of raw material of Lianhua-Qinwen capsule through systematical isolation and identification methods,as a result,17 compounds were isolated and elucidated from it,which provided a strong research data for the chemical basis of Lianhua-Qinwen capsule.

Key words: Lianhua-Qinwen capsule, chemical constituents, lignan, anthraquinone