天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (10): 1643-1648.doi: 10.16333/j.1001-6880.2021.10.003

• 研究论文 • 上一篇    下一篇

GC-MS联用技术分析麝鼠香和麝香化学成分差异

孙菲菲1,2，张振凌1,2,3*，梁迪1，余海英1，郑旭亚1,2，黄亚森1,2   

  1. 1河南中医药大学药学院；2河南省中药特色炮制技术工程研究中心；3呼吸疾病中医药防治省部共建协同创新中心，郑州 450008
  • 出版日期:2021-10-28 发布日期:2021-10-28
  • 基金资助:
    公益性行业专项——中药炮制技术传承基地建设(00 104296)；河南中医药大学2020年度研究生科研创新项目（2020KYCX021）

GC-MS analysis of the differences in the chemical components of muskrat and musk

SUN Fei-fei1,2,ZHANG Zhen-ling1,2,3*,LIANG Di1,YU Hai-ying1,ZHENG Xu-ya1,2,HUANG Ya-sen1,2   

  1. 1College of Pharmacy,Henan University of Chinese Medicine;2Henan Research Center for Special Processing Technology of Chinese Medicine;3Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R.China,Zhengzhou 450008,China
  • Online:2021-10-28 Published:2021-10-28

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摘要： 建立麝鼠香、麝香化学成分分析方法及环十五烷酮的含量测定方法，分析麝鼠香、麝香化学成分异同。采用GC-MS对其化学成分进行分析并测定环十五烷酮的含量，使用NIST标准质谱图库进行检索，结合相关文献对峰进行鉴定，并通过峰面积归一化法计算各化学成分的相对含量。从麝鼠香中检测出58个色谱峰，鉴定出化合物23个，占总峰面积的90.38%。麝香中共检测出43个色谱峰，鉴定出化合物19个，占总峰面积的91.21%。两者含有的相同成分有6个，包括十四烷酸，环十五烷酮，十六烷酸，油酸，硬脂酸，胆固醇。麝鼠香和麝香中主要含有环烷酮类、脂肪酸类以及甾体类化合物，二者成分种类有一定的相似性。

关键词: 麝鼠香, 麝香, 气质联用, 化学成分, 环十五烷酮

Abstract:

To establish the analysis method for the chemical constituents of muskrat and musk,determine the content of cyclopentadecanone,and analyze the similarities and differences of chemical compositions of muskrat and musk.The chemical components were analyzed and the content of cyclopentadecanone was determined by GC-MS.The peak was identified by NIST standard mass spectrometry library and relevant literature,and the relative content of each chemical component was calculated by peak area normalization method.Fifty-eight chromatographic peaks were detected from muskrat and 23 compounds were identified,accounting for 90.38% of the total peak area.A total of 43 chromatographic peaks were detected in musk and 19 compounds were identified,accounting for 91.21% of the total peak area.Both contain 6 identical ingredients,including tetradecanoic acid,cyclopentadecanone,hexadecanoic acid,oleic acid,octadecanoic acid,and cholesterol.Muskrat and musk mainly contain cycloalkanones,fatty acids and steroidal compounds,which have certain similarities in composition types.

Key words: muskrat, musk, GC-MS, chemical composition, cyclopentadecanone

中图分类号:  R282

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