天然产物研究与开发 ›› 2023, Vol. 35 ›› Issue (8): 1431-1441.doi: 10.16333/j.1001-6880.2023.8.016

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槟榔化学成分、药理、毒性研究进展及质量标志物预测分析

策力木格1，许   良2*   

  1. 1内蒙古民族大学蒙医药学院；2内蒙古民族大学化学与材料学院，通辽 028000
  • 出版日期:2023-08-28 发布日期:2023-08-30
  • 基金资助:
    国家自然科学基金（81560702）；蒙药研发国家地方联合工程研究中心开放基金（MDK2021034）；内蒙古自治区直属高校基本科研业务费项目（GXKY22137）；内蒙古自治区研究生科研创新项目（B20210204Z）

Research progress in chemical composition,pharmacology and toxicity of Areca Semen and prediction and analysis of its quality markers

Celimuge1,XU Liang2*   

  1. 1Mongolian Medical College,Inner Mongolia Minzu University;2College of Chemistry and Materials Science,Inner Mongolia Minzu University,Tongliao 028000,China
  • Online:2023-08-28 Published:2023-08-30

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摘要：

槟榔是我国常用的中药材，被列为四大南药之首，槟榔果实又为咀嚼嗜好品，具有广泛的药理活性又具毒性。近年来，国内外学者关于槟榔研究逐渐深入，槟榔中化学成分类型较多，具有多种药理作用，本文对其化学成分、药理作用、毒性作用等进行归纳总结的基础上从槟榔特有化学成分、可测成分、传统药性功效、炮制对化学成分的影响、入血成分和等多个方面进行槟榔质量标志物预测分析，筛选可作为槟榔质量标志物的首选成分及备选成分。为建立槟榔质量控制与评价体系提供参考。

关键词: 槟榔, 化学成分, 药理作用, 毒性作用, 质量标志物

Abstract:

Arecae Semen is a commonly used Chinese herbal medicine in China,and is listed as the first of the four southern medicines.Areca nut is also a chewing hobby,which has a wide range of pharmacological activities and toxicity.In recent years,domestic and foreign scholars have gradually deepened their research on Arecae Semen.There are many types of chemical components in Arecae Semen,which have a variety of pharmacological effects.Based on the summary of its chemical components,pharmacological effects,toxic effects,clinical applications,and consumption,this paper analyzes the specific chemical components,measurable components,traditional medicinal efficacy,the impact of processing on chemical components The blood components were used to predict and analyze the quality markers of Arecae Semen,and the preferred and alternative components of Arecae Semen quality markers were screened.It provides reference for establishing quality control and evaluation system of Arecae Semen.

Key words: Arecae Semen, chemical composition, pharmacological action, toxic effect, quality marker

中图分类号:  R917

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