天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (11): 1901-1909.doi: 10.16333/j.1001-6880.2021.11.013

• 开发研究 • 上一篇    下一篇

驼血多肽对运动训练大鼠骨骼肌线粒体能量代谢及肌组织自由基代谢的影响

王艳,李洁*   

  1. 西北师范大学体育学院,兰州 730070
  • 出版日期:2021-11-28 发布日期:2021-12-02
  • 基金资助:
    国家自然科学基金(31760295)

Effects of camel blood polypeptide on energy metabolism in mitochondrial and free radical metabolism in tissue of rats skeletal muscle after exercise training

WANG Yan,LI Jie*   

  1. College of Physical Education,Northwest Normal University,Lanzhou 730070,China
  • Online:2021-11-28 Published:2021-12-02

摘要: 探讨驼血多肽对运动训练大鼠骨骼肌线粒体能量代谢及肌组织自由基代谢的影响。大鼠随机分为6组(n=10):对照组(C)、运动训练组(E)、驼血多肽组(P)、驼血多肽+运动训练组(PE)、牛磺酸组(T)和牛磺酸+运动训练组(TE)。E、PE、TE组每日进行跑台运动训练,P和PE组灌胃驼血多肽,T和TE组灌胃牛磺酸。6周后,与E组相比,PE组腓肠肌GSH-Px活性显著升高(P﹤0.01),ROS显著下降(P﹤0.01)。驼血多肽结合运动训练可提高骨骼肌抗氧化能力,减少自由基的产生,且效果优于单纯运动训练。

关键词: 驼血多肽, 有氧运动, 三羧酸循环, 呼吸链, 自由基

Abstract:

To investigate the effects of camel blood polypeptide on mitochondrial energy metabolism and free radical metabolism of skeletal muscle in exercise-trained rats.The rats were randomly divided into 6 groups (n=10):control group (C),exercise training group (E),camel blood polypeptide group (P),camel blood polypeptide + exercise training group (PE),taurine group (T),taurine + exercise training group (TE).The E,PE and TE groups were given daily treadmill training,the P and PE groups were gavage with camel blood peptides,and the T and TE groups were gavage with taurine.After 6 weeks,compared with E group,the gastrocnemius GSH-Px activity of PE group was significantly increased (P﹤0.01),while ROS was significantly decreased (P﹤0.01).Camel blood polypeptide combined with exercise training can improve the antioxidant capacity of skeletal muscle and reduce the generation of free radicals,which have better effect than that of exercise training alone.

Key words: camel blood polypeptide, aerobic exercise, tricarboxylic acid cycle, respiratory chain, free radical

中图分类号:  Q445