中药花椒化学成分及其防治神经精神疾病的研究进展

doi:10.16333/j.1001-6880.2021.11.020

天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (11): 1969-1981.doi: 10.16333/j.1001-6880.2021.11.020

中药花椒化学成分及其防治神经精神疾病的研究进展

张红，杨庆，陈颖*，朱晓新*

中国中医科学院中药研究所，北京 100700

出版日期:2021-11-28 发布日期:2021-12-02
基金资助:
国家自然科学基金（82074103）；重大新药创制科技重大专项（2017ZX09101002-002-008）；载人航天工程医学实验领域项目（HYZHXM05003）

Research progress on chemical constituents of Zanthoxyli Pericarpium and its prevention and treatment of nervous and mental diseases

ZHANG Hong,YANG Qing,CHEN Ying*,ZHU Xiao-xin*

Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

Online:2021-11-28 Published:2021-12-02

摘要/Abstract

摘要： 中药花椒为芸香科植物青椒和花椒的干燥成熟果皮，富含挥发油类、生物碱类、酰胺类、黄酮及其糖苷类、香豆素类、木脂素类等成分。花椒的中医临床应用历史悠久，主要功效为温中止痛、杀虫止痒。近年来发现中药花椒在防治中枢神经系统疾病方面有显著疗效，尤其是花椒及其活性成分在益智、健脑、抗抑郁、治疗阿尔茨海默症、镇痛等方面的药理作用得到广泛的重视。本文对中药花椒的化学成分、在中枢神经系统的药理作用及其相关靶点做较为全面的总结，以期为中药花椒防治神经精神疾病的临床应用提供科学依据和参考。

关键词: 中药花椒, 山椒素, 改善记忆, 神经精神疾病, 作用靶点

Abstract:

The traditional Chinese medicine Zanthoxyli Pericarpium is the dried and mature pericarps of the Rutaceae plant Zanthoxylum schinifolium Sieb.et Zucc.and Zanthoxylum bungeanum Maxim.,rich in volatile oils,alkaloids,amides, flavonoids and their glycosides,coumarins,lignans and other ingredients.Zanthoxyli Pericarpium has a long history of clinical application in traditional Chinese medicine.Its main effects are warming and relieving pain,killing insects and relieving itching.In recent years,it has been found that Zanthoxyli Pericarpium has a significant effect on the prevention and treatment of central nervous system diseases.In particular,the pharmacological effects of Zanthoxyli Pericarpium and its active ingredients in improving intelligence,strengthening brain,anti-depressive,treating Alzheimer's disease,and analgesia have received extensive attention.This article provides a comprehensive summary of the chemical components of the traditional Chinese medicine Zanthoxyli Pericarpium,its pharmacological effects in the central nervous system and related targets,in order to provide a scientific basis and reference for the clinical application of the traditional Chinese medicine Zanthoxyli Pericarpium to prevent and treat neurological mental diseases.

Key words: traditional Chinese medicine Zanthoxyli Pericarpium, sanshool, improve memory, nervous and mental disease, targets of action

中图分类号: R284 R961

张红, 杨庆, 陈颖, 朱晓新. 中药花椒化学成分及其防治神经精神疾病的研究进展[J]. 天然产物研究与开发, 2021, 33(11): 1969-1981.

ZHANG Hong, YANG Qing, CHEN Ying, ZHU Xiao-xin.

Research progress on chemical constituents of Zanthoxyli Pericarpium and its prevention and treatment of nervous and mental diseases

[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(11): 1969-1981.

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中药花椒化学成分及其防治神经精神疾病的研究进展

Research progress on chemical constituents of Zanthoxyli Pericarpium and its prevention and treatment of nervous and mental diseases

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