天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (3): 521-533.doi: 10.16333/j.1001-6880.2021.3.020

• 综述 • 上一篇    

中药抗卵巢癌作用及机制研究新进展

文敏1,2,3,4,周欣1,2,3,4,赵超1,2,3,4,龚小见1,2,3,4*   

  1. 1贵州师范大学 贵州省山地环境信息系统与生态环境保护重点实验室;2喀斯特山地生态环境保护与资源利用协同创新中心;3贵州省药物质量控制及评价技术工程实验室;4天然药物质量控制研究中心,贵阳 550001

  • 出版日期:2021-03-28 发布日期:2021-04-01
  • 基金资助:
    贵州省高层次创新人才培养项目(黔科合人才[2015]4003)

New advances in research on anti-ovarian cancer effect and mechanism of traditional Chinese medicine

WEN Min1,2,3,4,ZHOU Xin1,2,3,4,ZHAO Chao1,2,3,4,GONG Xiao-jian1,2,3,4*   

  1. 1Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University;2Collaborative Innovation Center for Karst Mountain Ecological Environmental Protection and Resource Utilization (Project of Education Department of Guizhou Province),Guizhou Normal University;3Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine,Guizhou Normal University;4 Research Center for Quality Control of Natural Medicine,Guizhou Normal University,Guiyang 550001,China

  • Online:2021-03-28 Published:2021-04-01

摘要: 卵巢癌是女性常见的生殖器官恶性肿瘤之一,严重威胁着女性的生殖健康。中药治疗卵巢癌具有多靶点、多途径、毒副作用小等特点,近年来已成为国内外学者的研究热点。本文系统总结了中药复方药、植物药(多糖、黄酮类、生物碱、酚类、萜类、醌类、皂苷、酯类、挥发油、醚类)、动物药及矿物药抗卵巢癌的活性及作用机制,并初步分析了中药有效成分抗卵巢癌的构效关系,以期为抗卵巢癌药物的深入研究与应用提供参考。


关键词: 卵巢癌, 中药, 活性, 作用机制, 构效关系

Abstract:

Ovarian cancer is one of the common malignant tumors of female reproductive organs,which seriously threatens female reproductive health.The treatment of ovarian cancer with traditional Chinese medicine has the characteristics of multi-target,multi-channel and small side effects,which has become the research focus of scholars at home and abroad in recent years.This paper systematically summarized the anti-ovarian cancer activity and mechanism of Chinese herbal formula,plant medicine (polysaccharides,flavonoids,alkaloids,phenols, terpenes,quinones,saponins,esters,volatile oil,ethers),animal medicine and mineral medicine,furthermore,the structure-activity relationship of the effective ingredients of traditional Chinese medicine against ovarian cancer was preliminarily analyzed,which could provide a reference for the in-depth research and application of anti-ovarian cancer drugs.

Key words: ovarian cancer, traditional Chinese medicine, activity, mechanism of action, structure-activity relationship

中图分类号:  R273