Natural products have anti-inflammatory,anti-oxidant,hypoglycemic,regulating blood lipid,liver protection and other activities.Recent studies have shown that natural products can affect the behavioral changes of tumor cells,such as inhibiting the proliferation,migration and invasion of tumor cells,thus playing an anti-tumor activity.This paper summarizes the antitumor effect and mechanism of myricetin and dihydromyricetin in recent years,It not only provides ideas and research directions for follow-up research,but also puts forward new ideas for preclinical medication for experimental data support.