NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (4): 514-518.doi: 10.16333/j.1001-6880.2016.4.008

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Effects of Flavonoid and Flavone from Eucommia ulmoides Oliv. on Proliferation of Splenocytes and Production of IL-2 and IFN-γ in Mice

WANG Zhi-hong1,LEI Ming-sheng1,2,3,PENG Sheng1,ZHENG Yang1,SHI Li-juan1,PENG Mi-jun1*   

  1. 1 Key Laboratory of Hunan Forest Products and Chemical Industry Engineering,State and Local Joint Engineering Laboratory of Eucommia ulmoides Oliv.Comprehensive Utilization Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients Jishou University,Zhangjiajie 427000,China; 2 Zhongnan Hospital of Wuhan University,  Wuhan 430071,China; 3 The Zhangjiajie People’s Hospital of Hunan,Zhangjiajie 427000,China
  • Online:2016-04-30 Published:2016-05-13

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Abstract: In this study,MTT and ELISA methods were used to investigate the effects of flavonoid and flavone from Eucommia ulmoides Oliv.on prolifeation of splenocytes and production of IL-2 and IFN-γ in mice.The results showed that flavonoid extract of E.ulmoides Oliv.and quercetin can siganificantly upregulate prolifeation and production of IL-2 and IFN-γ in lymphocytes stimulated by ConA or LPS.Along with the extension of time,compared with the blank group,the experimental results changed significantly.The results of multiple significance analysis showed that there was certain dose concentration dependence.However,kaempferol can effectively inhibit proliferation and production of cytokine in a certain concentration range.

Key words: flavonoid of Eucommia ulmoides Oliv., quercetin, kaempferol, immunity, lymphocytes

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