Abstract: The objective of this study was to observe the effect and mechanism of resveratrol on cerebral ischemia reperfusion injury in rats.The Model of cerebral ischemia-reperfusion injury were induced by ligating middle cerebral artery in rats.The rats for study was randomly divided into Sham group,cerebral ischemia reperfusion injury (IRI),Resveratrol group (RSV) and Nimodipine group (NIM).The effect of RSV on the cerebral infarct volume and nervous behavior were evaluated.the expression levels of tumor meerosis factor-α (TNF-α),Monocyte chemotaxis factor-1 (MCP-1),interleukin-6 (IL-6),Wnt, β-catenin,cyclin D1,surviving,Bax and BCL-2 were examined.The result showed that resveratrol could significantly improve the nervous behavior,decrease cerebral infarct volume and attenuate the expression of TNF-α,MCP-1,IL-6 and Bax with increasing the expression of Wnt,β-catenin,cyclin D1,survivin and BCL-2 (P<0.05).Therefore,it can be concluded that resvtrol can decrease cerebral ischemia-reperfusion injury by activating Wnt/β-catenin signaling pathway.

Key words: resveratrol, cerebral ischemia-reperfusion injury, Wnt/&beta, -catenin