Abstract: Along with the in-depth research of marine drugs and leading compounds,sponge-associated microbes attract the interest of researchers,because of its great varieties and complicated metabolites.A number of bioactive compounds with unique structural features and strong biological activities were isolated from sponge-associated fungi,including peptides,alkaloids,polyketides,terpenoids.This paper reviewed the types of compound structures and their biological activities of new natural products from sponge-derived fungi reported in recent years.

Key words: Sponge, fungi, natural products, bioactivity