NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (5): 856-862.doi: 10.16333/j.1001-6880.2018.5.020

Special Issue: 抗肝损伤专题

• Article • Previous Articles     Next Articles

Protective effect of Thyme Essential Oil on Thioacetamide-induced Liver Injury in Mice

LIU Xing1, WANG Rui2, ZHANG Run-guang1, WANG Jing1,3, WANG Qian1, ZHANG You-lin1*   

  1. 1College of Food Engineering and Nutritional Science,Shaanxi Normal University,Xi’an,710119,China; 2Shaanxi Provincial Forestry Technology Promotion Station,Xi’an,710082,China; 3College of Life Science and Food Engineering ,Xi’an ,710010,China  
  • Online:2018-06-04 Published:2018-06-04

Abstract: The study was to explore the antioxidant capacity of thyme essential oil and its potential protection effects on the liver of mice.The anti-oxidation activities of thyme essential oil were analyzed by DPPH· and ABTS·+ scavenging experiments.Besides,the acute liver injury model of Kunming mice by Thioacetamide (TAA) was also established,and the liver protection effects of thyme essential oil were assessed by determining the activity of ALT,AST and ALP in mice blood samples.After the homogenization of the liver tissue,the MDA,GSH contents and SOD,GSH-Px and CAT activities were further analyzed.The results suggested that thyme essential oil had significant anti-oxidation capacities and protection effects on the liver of the mice,especially when used at high doses.The study aimed to provide the theoretical foundation for the research and development of thyme essential oil.

Key words: thyme essential oil, antioxidant, thioacetamide, liver-protection

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