Indole alkaloids from Alstonia macrophylla

doi:10.16333/j.1001-6880.2020.4.011

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2020, Vol. 32 ›› Issue (4): 622-626. doi: 10.16333/j.1001-6880.2020.4.011

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Indole alkaloids from Alstonia macrophylla

ZHANG Jin-ping1,3,4,YAN Hui-jiao2,WANG Ya-lan1,3,4,WANG Zhi-wei2 *,WANG Xiao-jing1,3,4*

1School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,China;2Shandong Analysis and Test Center,Qilu University of Technology (Shandong Academy of Sciences),Jinan 2500140,China;3Institute of Materia Medica,Shandong Academy of Medical Sciences;4Key Laboratory for Biotech-Drugs Ministry of Health,Key Laboratory for Rare-Uncommon Diseases of Shandong Province,Jinan 2500620,China

Online:2020-04-28 Published:2020-06-05

Abstract

Abstract:

In order to investigate the chemical constituents and biological activities of Alstonia macrophylla, six monoterpenoid indole alkaloids,namely vallesamine (1),picrinine (2),khasuanine A(3),scholaricine(4),echitamine(5),strictosamide(6) were isolated from leaves and twigs of Alstonia macrophylla by repeated column chromatography over silica gel,Sephadex G and Prep-HPLC.Their structures were elucidated based on NMR and MS spectroscopic data.Compounds 3 and 6 were firstly obtained from this genus,and compounds 1,2,4 and 5 were isolated from this plant for the first time.All compounds were evaluated the cytotoxicity of HCT-116 and DLD-1.Among them,compounds 2 and 4 had certain cytotoxicity,and compound 4 showed DLD-1 inhibitory activity with an IC₅₀ value of 16.7 μg/mL.

Key words: Alstonia macrophylla, indole alkaloids, bioactivity, chemical constituents ,

CLC Number:

R284.1

ZHANG Jin-ping, YAN Hui-jiao, WANG Ya-lan, WANG Zhi-wei , WANG Xiao-jing, . Indole alkaloids from Alstonia macrophylla[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(4): 622-626.

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URL: http://www.trcw.ac.cn/EN/10.16333/j.1001-6880.2020.4.011

http://www.trcw.ac.cn/EN/Y2020/V32/I4/622

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Indole alkaloids from Alstonia macrophylla

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