In order to distinguish Chuan Citrus Reticulata Pericarpium (CCRP) from its adulterant,the flavonoids in CCRP and its adulterant were determined by UHPLC-MS/MS.The data of primary and secondary spectra detected by UHPLC-MS/MS were qualitatively analyzed based on the public metabolomics database,and the compounds were analyzed by principal component analysis (PCA),partial least squares-discriminant analysis (OPLS-DA) and cluster analysis.Finally,a total of 228 flavonoids compounds including 132 flavones,36 flavonols,20 flavanones,21 anthocyanins,7 isoflavones,and 12 polyphenols were identified by database searching,of which 15 specific compounds were identified in CCRP and 16 specific compounds were identified in adulterant.The CCRP and its adulterant could be accurately distinguished by PCA,OPLS-DA and clustering analysis.The experimental results show that the method of metabolomics analysis based on UHPLC-ESI-MS/MS technique can effectively distinguish CCRP from its adulterant,which can be used as an effective method to differentiate CCRP and the adulterant,and the results also provide reference for the authenticity identification and quality evaluation of other traditional Chinese medicine (TCM).