Oxidative stress can cause a series of diseases by destroying the oxidative balance in the cell and damaging the system or tissue.The nuclear factor erythroid 2 related factor 2 (Nrf2) regulated by Kelch-like ECH-associated protein 1 (Keap1) protein is a key factor in cellular oxidative stress response.To protect cells from oxidative damage,Nrf2 is separated from Keap1,which enters the nucleus and combines with the antioxidant response element (ARE),increasing the expression of phase Ⅱ detoxification enzyme.It is found that natural products are of great significance for drug research and development,and most of Nrf2 activators are also natural products or derivatives of natural products.This article describes the mechanism of action of the Nrf2-Keap1 signaling pathway and common natural product-oriented Nrf2 activators.