Oxygen is an essential material basis for life activities.Hypobaric hypoxia in high altitude,respiratory diseases,cardiovascular diseases and other internal and external factors can lead to mitochondrial damage,energy metabolism disorder,oxidative stress,inflammation and a series of reactions,and damage the body.It is particularly important to develop safe and effective therapeutic drugs.In recent years,a large number of studies have shown that Chinese medicine has great potential in anti-hypoxia.This paper summarizes the research progress of anti-hypoxic monomeric compound,extracts and compounds of Chinese medicine,providing ideas for the in-depth study and development of anti-hypoxia Chinese medicine,and providing reference for its clinical application.