Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used for the simultaneous determination of kaempferol-3-O-α-L-rhamnoside,quercetin,quercetin-3-O-β-D-xylopyranoside,quercetin-3-O-α-L-arabinofuranoside,kaempferol-3-O-(2″-E-p-coumaroyl)-α-L-rhamnoside and kaempferol-3-O-(2″,4″-di-E-p-coumaroyl)-α-L-rhamnoside of 6 flavonoids in Lindera aggregata leaf. Kinete XB-C₁₈ column(2.1 mm×50 mm,1.7 μm) was used.The mobile phase was acetonitrile(A)-0.1% formic acid aqueous solution(B) in gradient elution mode(0-0.5 min,10% A;0.5-2 min,10%→30% A;2-6 min,30%→70% A;6-7 min,70%→90%A;7-8 min,90% A;8-9 min,90%→10%A;9-10min,10%A) with the flow rate of 0.2 mL/min.The injection volume was 1.0 μL and the column temperature was 30 ℃.Electrospray ionization source (ESI) and multiple reaction monitoring (MRM) were used combined with negative scanning switch.The linear relationship between the concentration and peak areas of the ten composition were all linear (r＞0.999).The average recoveries were between 98.15%-102.84%,RSD were between 0.60%-2.43%.The entropy weight TOPSIS method was used to analyze and evaluate the relative quality of the L. aggregata leaf from Tiantai,Zhejiang.This method is rapid,sensitive,accurate and reliable,and can provide a basis for quantitative analysis and comprehensive evaluation of the internal quality of the main flavonoids in the L. aggregata leaf.