To establish a method for HPLC fingerprint,chemical pattern recognition and multi-index component determination of Bupleurum Radix-Paeoniae Radix Alba (BR-PR) formula granules The chromatography was performed on COSMOSIL 5C₁₈-MS-Ⅱ (250 mm×4.6 mm,5 μm) column.Acetonitrile-0.1% phosphoric acid water was mobile phase and gradient elution;Volume flow rate was 1.0 mL/min;The detection wavelengths were 210 nm and 230 nm;Column temperature was 30 ℃.The HPLC fingerprint was established,and the similarity evaluation,clustering analysis (CA) and principal component analysis (PCA) were used to study the fingerprint of 15 batches of BR-PR formula granules.The contents of four index components were determined simultaneously.The fingerprint established in this study identified 15 common peaks and identified four components of them.The similarity between the fingerprint of 15 batches of BR-PR formula granules medicine and the control fingerprint was all >0.90. Both CA and PCA could divide 15 batches of BR-PR formula granules into two categories.The multi-index component content determination method meets the requirements of methodological investigation,and the contents of four components are different in different degrees.The established method is simple and feasible,and can provide reference for the quality control and clinical use of BR-PR formula granules.