Astragali Radix,a widely used herbal medicine in traditional Chinese medicine,is extensively employed in both food and medicine.However,the inconsistent quality of Astragali Radix remains a significant issue due to various factors.The current evaluation method makes it challenging to control the quality of Astragali Radix,and it fails to effectively correlate with the efficacy of Astragali Radix in different compound formulas.This seriously impacts its efficacy and safety in clinical use.Therefore,it is urgent to explore the application of omics technologies,which possess holistic and systematic characteristics,in evaluating the quality of Astragali Radix.This study offers an overview of recent research findings,lighting the application and progress of omics technologies, including metabolomics,transcriptomics,genomics,and proteomics, in the quality control of Astragali Radix.It delves into various aspects such as variety,origin,cultivation method,adversity,and concoction processing.Furthermore,it examines the pharmacological mechanisms of action,including anti-fatigue,anti-heart failure,prevention and treatment of endocrine diseases,and anti-tumor properties.Finally,it offers thoughtful reflections on the future of omics technologies in the field of Astragali Radix research.This study aims to provide new ideas and methods for the establishment of a comprehensive and systematic quality assessment system for clinical rational drug use.