Cytotoxic Metabolites of Endophytic Fungus Colletotrichum sp. from Aristolochia spp.

doi:A

Abstract

Abstract: Six compounds were isolated from the fermented rice substrate of endophytic fungus Colletotrichum sp. isolated from Aristolochia spp. in Zhejiang Province. They were identified as 7-hydroxy-10-oxodehydrodihydrobotrydial (1), alternariol (2), alternariol 5-O-methyl ether (3), altertoxin I (4), tentoxin (5), and dihydrotentoxin (6) on the basis of spectroscopic data analyses. All the compounds were firstly isolated from Colletotrichum sp., among which compounds 1-4 showed cytotoxic activity against both lung cancer cell line A549 and breast cancer cell line MDA-MB-231.

Key words: Bazhen decoction, HPLC, urine, SPE, depurating methods

CLC Number:

R284.2

YANG Zhi-jun, YIN Yu,WANG Zhi-qiang, YANG Tian, CHEN Dai-jie. Cytotoxic Metabolites of Endophytic Fungus Colletotrichum sp. from Aristolochia spp.[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(3): 329-332.

References

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