Progress on Anti-inflammatory Effects and Mechanism of Propolis

doi:A

Abstract

Abstract: Propolis is a strong anti-inflammatory agent and indicated improvement of various inflammations. In this article we reviewed the effect of propolis on inflammation and proinflammatory mediators. The possible action mechanism and active composition of propolis were analyzed. In addition, the theory about combination of anti-inflammatory drug and propolis showed synergic effect on inflammation gives out the suggestion to exploitation of anti-inflammatory drugs.

Key words: propolis, anti-inflammatory, research progress

CLC Number:

R961

LI Ying-hua, ZHU Wei, HU Fu-liang. Progress on Anti-inflammatory Effects and Mechanism of Propolis[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(6): 856-.

References

1 Krell R.Value-added products from beekeeping,Fao Agricultural Services Bulletin No.124.Rome:Food and Agriculture Organization of the United Nations,1996:157-194.
2 Banskota AH,et al.Recent progress in pharmacological research of propolis.Phytother Res,2001,15(7):561-571.
3 Sforcin JM.Propolis and the immune system:a review.J Ethnopharmacol,2007,113(1):1-14.
4 Sosa S,et al.Topical antiinflammatory activity of an innovative aqueous formulation of actichelated propolis vs two commercial propolis formulations.Phytother Res,2007,21(9):823-826.
5 Fitzpatrick LR,et al.Caffeic acid phenethyl ester,an inhibitor of nuclear factor-kappaB,attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats.J Pharmacol Exp Ther,2001,299(3):915-920.
6 Montpied P,et al.Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures.Brain Res Mol Brain Res,2003,115(2):111-120.
7 Guan HM(关怀敏),et al.Inflammation and Coronary Heart Disease(炎症与冠心病).Shanghai:Shanghai University of TCM.Publishing House,1999:27-54.
8 Naito Y,et al.Antiinflammatory effect of topically applied propolis extract in carrageenan-induced rat hind paw edema.Phytother Res,2007,21(5):452-456.
9 Santos VR,et al.Efficacy of Brazilian propolis gel for the management of denture stomatitis:a pilot study.Phytother Res,2008,22(11):1544-1547.
10 Paulino N,et al.Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis.Planta Med,2006,72(10):899-906.
11 Paulino N,et al.Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle.J Pharmacol Sci,2003,93(3):307-313.
12 Li YH(李英华).Study on the anti-inflammation and immunity mechanism of propolis.Zhejiang:Zhejiang University(浙江大学),Master.2002.
13 Cirino G,et al.Nitric oxide and inflammation.Inflamm Allergy Drug Targets,2006,5(2):115-119.
14 Tak PP,Firestein GS.NF-kappaB:a key role in inflammatory diseases.J Clin Invest,2001,107(1):7-11.
15 Aslan A,et al.Effectiveness of mesalamine and propolis in experimental colitis.Adv Ther,2007,24(5):1085-1097.
16 Tan-No K,et al.Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema.Biol Pharm Bull,2006,29(1):96-99.
17 Woo KJ,et al.Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity.FEBS Lett,2005,579(3):705-711.
18 Hu F,et al.Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models.J Ethnopharmacol,2005,100(3):276-283.
19 Khayyal MT,et al.A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients.Fundam Clin Pharmacol,2003,17(1):93-102.
20 Shin EK,et al.Chrysin,a natural flavone,improves murine inflammatory bowel diseases.Biochem Biophys Res Commun,2009,381(4):502-507.
21 Song YS,et al.Ethanol extract of propolis inhibits nitric oxide synthase gene expression and enzyme activity.J Ethnopharmacol,2002,80(2-3):155-161.
22 Abdel-Latif MM,et al.Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells.Br J Pharmacol,2005,146(8):1139-1147.
23 Choi K,Choi C.Differential regulation of c-Jun N-terminal kinase and NF-kappaB pathway by caffeic acid phenethyl ester in astroglial and monocytic cells.J Neurochem,2008,105(2):557-564.
24 Bose JS,et al.Downregulation of inflammatory responses by novel caffeic acid ester derivative by inhibiting NF-kappa B.J Clin Immunol,2009,29(1):90-98
25 Sabir A,et al.Histological analysis of rat dental pulp tissue capped with propolis.J Oral Sci,2005,47(3):135-138.
26 Borrelli F,et al.Phytochemical compounds involved in the anti-inflammatory effect of propolis extract.Fitoterapia,2002,73 Suppl 1:S53-63.
27 Blonska M,et al.Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages.J Ethnopharmacol,2004,91(1):25-30.
28 Oksuz H,et al.Effect of propolis in the treatment of experimental Staphylococcus aureus keratitis in rabbits.Ophthalmic Res,2005,37(6):328-334.
29 Duran N,et al.The protective role of topical propolis on experimental keratitis via nitric oxide levels in rabbits.Mol Cell Biochem,2006,281(1-2):153-161

[1]	CHEN Zhong-yi, ZHU An-ming, YANG Xiu-xia, DUAN Han-yu, LIU Jun-xi, XIAO Feng-kun, QU Li-ping. Structural characterization and anti-inflammatory activity of neutral homogeneous polysaccharides from Prinsepia utilis oil meal [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 37-45.
[2]	CUI Wen-jin, LIANG Kai, LYU Jin-peng, ZHANG Guang-jie, LIU Shu-chen. Chemical constituents from Xanthoceras sorbifolia seed meal and their anti-inflammatory activity [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 61-68.
[3]	SHEN Man, HE Zhi-long, JIANG Li, BAI Chun-mei, WANG Yang, LI Yue-ting, LI Yong-jun. Chemical constituents and anti-inflammatory activity of pine cone of Pinus massoniana Lamb. [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 69-76.
[4]	LIU Wen-bin, YI Guo-qi, SONG Yu-ying, ZHANG Yi, ZHANG Jing, LIU Yue. Diterpenoid alkaloids from Aconitum pendulum Busch and their anti-inflammatory activities [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 77-85.
[5]	XU Jia-hui, LI Xin, HUO Jing-chen, CUI Chun-li, ZHANG Ying, MA Yu-lin, ZHANG Juan. Pharmacodynamics and preparation of aloperine thermosensitive gel for vaginal use [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 94-106.
[6]	QI Hui, LI Ying-tong, LI Xin-cong, LIU Yan-ze, WANG Cai-fang. Antioxidant and anti-inflammatory activities of Cichorium intybus L. [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 76-82.
[7]	LIU Hai-feng, ZHAO Rong-mei2, XU Hong, MANAER Tabusi, PAN Le1, JIN Lu, AYUPBEK Amatjan. Research progress on chemical compositions,pharmacological activities and quality evaluation of Viola kunawarensis Royle [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 162-174.
[8]	LIU Tian-zi, ZHANG Qian, LU Mei-long, LAI Qiong, HAN Zhu-zhen, GU Li-hua, YANG Li, WANG Zheng-tao. Chemical constituents from Lepidii Semen [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(9): 1605-1617.
[9]	ZOU Jin-lian, ZHU Kui-lin, YIN Rui, DENG Mao-xin, WANG Hai-ming, CHEN Zhang-xian, LI Wei-jiao, DONG Fa-wu. Chemical constituents from EtOAc extract of Angelicae Sinensis Radix and their anti-inflammatory activities [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(9): 1645-1652.
[10]	HOU Bao-long, LI Mao-hao. Anti-inflammatory and antioxidant activities of Thymus quinquecostatus Celak essential oil in vitro [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(9): 1679-1688.
[11]	XIA Xiao-pei, MA Guang-li , ZHAO Jing, DENG Ming-zhu, LIU Cui-cui. Therapeutic effect and mechanism of Hippophae rhamnoides polysaccharide on pulmonary fibrosis in mice based on the TGF-β1/Smad axis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(8): 1504-1512.
[12]	HUANG Ying, JIN Zi-yue, MA Guo-xu, RU Qing, YU De-fa, FU Zhi-wen, LUO Jiao-yang, YANG Mei-hua. Chemical constituents from Cinnamomi Camphorae Radix and their anti-inflammatory activities [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(7): 1252-1258.
[13]	LU Mao-fang, WU Jian, JIANG Shi-qin, LU Man-xia, YOOK Chong-soo, LEE Geon-ho, DAI Ling, LIU Xiang-qian. Anti-inflammatory effects of four lupane-type triterpenoids from Acanthopanax gracilistylus W.W.Smith [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(7): 1259-1266.
[14]	XUE Fei-xia, YAN Hao, MEI Wen-li, YANG Li, CAI Cai-hong, DAI Hao-fu, WANG Hao, WANG Li-sheng. Phenolic components from n-butanol fraction of Cephalotaxus hainanensis and their anti-inflammatory activity [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(6): 1055-1061.
[15]	ZHANG Hong-yan, SUN Ran, WANG Si-rui, ZHANG Ling, SUN Yun-peng, YU Yang, LIU Jin-song, WANG Guo-kai. Secondary metabolites of endophytic fungus Alternaria brassicae from Salvia miltiorrhiza and its bioactivity [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(6): 1077-1084.