Antioxidant and Antifatigue Activities of Flavonoid from Codonopsis clematidea (Schrenk)

doi:A

Abstract

Abstract: This paper using the flavonoid from Codonopsis clematidea (Schrenk) of low, middle and high dosage mice 25d, then respecting comparing with control group. The results showed that Codonopsis clematidea (Schrenk) flavonoid could enhance the SOD activities of mice blood and liver, decrease the MDA content of mice blood and liver, obviously prolong the swimming time of loaded mice, increase the content of liver glycogen and muscle glycogen, and decrease the blood urea nitrogen in mice after swimming. These results indicate Codonopsis clematidea (Schrenk) flavonoid had the antioxidant and antifatigue function.

Key words: Codonopsis clematidea (Schrenk), flavonoid, mouse, antioxidant, antifatigue

CLC Number:

R151.3

WANG Jian-hong, YUAN Hui,Li Xue-hong . Antioxidant and Antifatigue Activities of Flavonoid from Codonopsis clematidea (Schrenk)[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(8): 1035-.

References

1 He Q(贺庆),Zhu EY(朱恩圆),Wang ZT(王峥涛),et al.Study on chemical constitutes of Codonopsis pilosula.Chin Pharm J(中国药学杂志),2006,41:10-12
2 Jin XJ(晋小军),Huang HY(黄惠英),Li GQ(李国琴),et al.Effect of different package onsaponins content of Codeonopsis filosulsa.Chin Wild Plant Resourse(中国野生植物资源),2002,21(5): 57-59
3 Zhu EY(朱恩圆),He Q(贺庆), Wang ZT(王峥涛),et al.Chemical study on the root of Codonopsis pilosula.J Chin Pharm Univ(中国药科大学学报),2001,32(2):94-95
4 Chen KK(陈克克).Research progress in Codonopisis pilosula.J Xi'an Arts Sci Coll,Nat Sci(西安文理学院学报(自然科学版)),2008,11(2):33-39
5 Cao L(曹丽),Luo CN(罗崇念),Bian QY(卞庆亚),et,al.Promotive effect of Codonopsis pilosula polysaccharide on IL-2 inductive activity and lymphocyte proliferative reaction in chickens.J Tradit Chin Vet Med(中兽医医药杂志),2004,23:3-4
6 He Q(贺庆),Zhu EY(朱恩圆),Wang ZT(王峥涛).Flavones isolated from Codonopsis xundianensis.Chin Pharm Sci(中国药学),2004,13:212-213
7 Li D(李都),Yin LK(尹林克).Wild plant of Chinese Xin Jiang(中国新疆野生植物).Urumuqi:Juvenile Publishing House 2006.90
8 Li YZ(李云志),Zeng FJ(曾凡骏).Isolation and structure identification of theflavonoid from the leaves of acer truncatum bunge.Nat Prod Res Dev(天然产物研究与开发),2006,18:426-427
9 Jia DY(贾冬英),Yao K(姚开),Lv YP(吕远平),et,al.Antioxidant activity research development of Citrus flavonoid.Guangdong Food Ind (广东食品工业),2002,18(4):66-68
10 Benavente-García O,Castillo J,Marin FR,et al.Uses and propertis of Citrus flavonoids.J Agric Food Chem 1997,45:4505-4516
11 Benavente-García O,Castillo J,del Rio Conesaet JA.Changes in neodiosmin levels during the development of Citrus aurantium leaves and fruits. Postulation of a neodiosmin biosynthetic pathway.J Agric Food Chem,1993,41:1916-1919
12 Wang ZY(王竹影).Effect of FDP fructose upon the capacity of exercise and resisting fatigue.J Chengdu Phys Educ Insit(成都体育学院学报),2002,28(3):94-96

[1]	GAN Ping-gui, DENG Ye-cheng, DENG Zhi-yong, LUO Hai-yu. In vitro antioxidant activity of hydrolysates of fly maggots [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(2): 384-392.
[2]	TANG Lin, LU Ai-juan, HU Chao, LI Hai-ying, GAO Yuan-hang, LI Hao, YANG Lei. Spectrum-effect relationship between HPLC fingerprint and in vitro antioxidant activity of Notoginseng Radix et Rhizoma and its processed products [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 1-12.
[3]	QIAO Wen-hao, LIN Zhi-qi, DONG Jun-fang, HU Wei-yan, ZHANG Rong-ping, CHEN Xing-long. Chemical constituents of Tripterygium hypoglaucum roots and their neuroprotective effects [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 86-93.
[4]	WANG Qian-fen, WU Jia-yin, SUN Ying-hui, XU Xiao-bo, ZHANG Yan-fang. Process optimization of ultrasound-assisted deep eutectic solvents extraction of total flavonoids from Sophorae Flos Immaturus and its antioxidant activity [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2026, 38(1): 121-131.
[5]	LI Cai-xia, SUN Xia, WANG Xue-lian, ZHAO Li-juan, PI Li, WEI Li-xin. Analysis of main components in different parts of Nardostachys jatamansi DC. [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 47-57.
[6]	LIU Jin-zhen, JIANG Rong-yue, WEI Qing, WANG Hai-jiao, WANG Zhi-wei, HAN Hui-pei, MA Xiao-jing. Comparative study on the constituents and biological activities of different basil essential oils [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 68-75.
[7]	QI Hui, LI Ying-tong, LI Xin-cong, LIU Yan-ze, WANG Cai-fang. Antioxidant and anti-inflammatory activities of Cichorium intybus L. [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 76-82.
[8]	HUANG Ying, CUI Ling, WANG Jian-qing, GONG Yu-rong, ZHANG Wen-han, YANG Guang-yao, ZHANG Wen-gen. Extraction optimization of total flavonoids from Indocalamus longiauritus organs [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 116-122.
[9]	WANG Yu-mei, WANG Ying, LI Na, LI Cong-ying. Correlation between total flavonoids and total polyphenols content with antioxidant activities of different extracts of Cynomorium songaricum [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(9): 1638-1644.
[10]	ZHENG Run-bo, RAN Ya-lan, PENG Shi-qin, LUO Kai, HE Mei-jun. Whitening and uric acid-lowering activities of Chaenomeles speciosa (Sweet) Nakai leaf extract [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(9): 1715-1723.
[11]	XIA Xiao-pei, MA Guang-li , ZHAO Jing, DENG Ming-zhu, LIU Cui-cui. Therapeutic effect and mechanism of Hippophae rhamnoides polysaccharide on pulmonary fibrosis in mice based on the TGF-β1/Smad axis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(8): 1504-1512.
[12]	MA Zu-wen, ZHANG Xin, ZHANG Pei, ZHANG Li, YANG Ting, MENG Fan-long. Protective effect of total flavonoids from Dracocephalum moldavica L. on the inflammatory responses to myocardial ischemia-reperfusion injury by the inhibition of NLRP3 inflammasome activation [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(8): 1513-1521.
[13]	LIN Jia-hui, YAN Jian-gang, XIE Guo, LIU Wen-li, MEI Ao-yu, LI Xiao-min, LIU Hong-xia. Study on whitening activity of Panax ginseng fermentation broth based on AGE-RAGE/MITF-TYR signaling pathway [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(7): 1208-1219.
[14]	RUAN Feng-mei, FU Wei-yang, HUANG Xiao-hong, HUA Ying-yue, HUANG Li-mei, LI Yu-feng. Protective mechanism of Hippophae rhamonides flavonoid extract on CCl4-induced acute liver injury in mice [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(7): 1228-1235.
[15]	SHU Qing, WU Ya-yu, TANG Yu-jun, YUAN Yi-fan, WANG Miao, ZHOU Guang-xiong. Chemical constituents from fruit hull of Camellia oleifera Abel. [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(7): 1243-1251.