NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2012, Vol. 23 ›› Issue (8): 1047-. doi: A

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Secondary Metabolites from Marine Fungus Fusarium sp.

LIU Tao1*, LI Zhan-lin2, WANG Yu2, TIAN Li3,4, PEI Yue-hu2, HUA Hui-ming2   

  1. 1School of Pharmaceutical Sciences, China Medical University, Shenyang 110001, China; 2Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; 3The First Institute of Oceanography SOA, Qingdao 266061, China; 4Qingdao University of Science & Technology, Qingdao 266042, China
  • Online:2012-09-06 Published:2012-10-15

Abstract: Five compounds were isolated and purified from the mycelia of marine fungus Fusarium sp. by using silica gel, Sephadex LH-20, open ODS column chromatography and HPLC. On the basis of spectral data and physicochemical properties, their structures were elucidated as 3?,15?-dihydroxyl-(22E,24R)-ergosta-5,8(14),22-triene-7-one (1), 3?,5?,9?-trihydroxyl-(22E,24R) -ergosta- 7,22-diene-6-one (2), (22E,24R)-ergosta-7,22-diene-3?,5?,6?-triol (3), 5?,8?-epidioxy-(22E,24R)-ergosta-6,22-dien-3?-ol (4), and amber acid (5). Compounds 1 and 2 were isolated for the first time from this genus of marine fungus.

Key words: marine fungus, Fusarium sp., secondary metabolite, ergosterol

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