Abstract: In the present study, effects of polysaccharides from seed residue of Hippophae rhamnoide L. (PSH) on serum glucose and lipid profiles in normal mice and nicotinamide-streptozotocin induced type 2-like diabetic rats were investigated. PSH were orally administered to normal mice (100, 200 and 400 mg/kg) and diabetic rats (50 and 100 mg/kg) once a day lasting for 20 and 21 days, respectively. At the end of experiments, the serum glucose, insulin, total cholesterol, triglyceride, glycosylated serum protein and hepatic glycogen levels of mice and rats were measured. The results showed that oral administration of PSH had no effect in normal mice both on serum glucose and lipids levels. As for type 2-like diabetic rats, the fasting serum glucose, glycosylated serum protein and total cholesterol were lowered significantly by PSH treatment, whereas serum insulin levels were increased significantly. These results suggested that PSH might have hypoglycemic and hypolipidaemic effects in type 2-like diabetic rats.

Key words: polysaccharides from seed residue of Hippophae rhamnoide L. (PSH), type 2-like diabetic rats, hypoglycemic effect