Abstract: Hyperuricemia is an increasing risk of metabolic syndrome in recent years.This study explored the effect and mechanism of gypenoside on serum uric acid concentration in hyperuricemic rats.The secondary hyperuricemia rat model induced by unreasonable dietary structure was made by intragastric administration of yeast and potassium oxonate.Indicators of hyperuricemic rats,including serum uric acid concentration,oxidase activity of xanthine in serum and uric acid excretion in 24 hours,were monitored.The results of biochemical detection showed that the concentration of serum uric acid in hyperuricemic rats of each gypenoside group were obviously lower than those in model group.In addition,the oxidase activity of xanthine in serum and uric acid excretion in 24 hours of gypenoside groups with different dosages had no significant differences.Hence,it was hypothesized that gypenoside played a role in inhibiting uric acid generation without inhibiting the activity of xanthine oxidase.On the other hand,there was no obvious difference in pH value of each group,while the concentration of serum uric acid in each gypenoside group were obviously higher than those in model group.Hence,it was hypothesized that gypenoside promoted the dissolution of serum uric acid in the urine.Based on these experimental results,it was concluded that gypenoside was beneficial for improving health status in patients with hyperuricemia by reducing the body's serum uric acid concentration via inhibiting generation and promoting excretion.

Key words: gynostemma, gypenoside, hyperuricemia, rats